{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:34:07Z","timestamp":1772998447711,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optimal antimicrobial therapy for Enterococcus faecium bloodstream infection (EFBSI) in the solid organ transplant (SOT) population is not well defined. The purpose of this study was to describe the pharmacotherapy and outcomes of EFBSI in SOT patients. This was a single\u2010center retrospective cohort of SOT patients with EFBSI from 2013 to 2019. Susceptibility testing was performed with Vitek<jats:sup>\u00ae<\/jats:sup> 2 or Etest. Estimates of optimal DAP pharmacokinetic\/pharmacodynamic exposures (dose &lt;10\u00a0mg\/kg, fAUC\/MIC &gt;27.4) were made from previously established literature and equations. Fifty\u2010one unique cases were included in the analysis. The median age was 61\u00a0years and liver (64%), intestinal (19%), and kidney (12%) were the most common organs transplanted. Most patients had indwelling central lines (75%) at the time of bacteremia; intra\u2010abdominal abscesses\/fluid collections were present in 44% of patients and 8% had endocarditis. Nineteen (37%) patients had polymicrobial infections. The most common definitive antimicrobial regimens were as follows: DAP plus beta\u2010lactam (46%), DAP monotherapy (18%), and LZD (25%). Of the 33 patients that received DAP, 21% of <jats:italic>E\u00a0faecium<\/jats:italic> isolates developed DAP resistance. 30\u2010day mortality was 25% overall but higher in patients who received an initial DAP dose &lt;10\u00a0mg\/kg (43% vs 13%). Vancomycin\u2010resistance, severity of illness, neutropenia, and source control were also associated with mortality. Inadequate DAP dosing for EFBSI may be associated with mortality in the SOT population. Larger, controlled analyses are necessary to determine the impact of optimized pharmacodynamics in this population.<\/jats:p>","DOI":"10.1111\/tid.13251","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T09:33:29Z","timestamp":1580376809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment and outcomes of <i>Enterococcus faecium<\/i> bloodstream infections in solid organ transplant recipients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-8736","authenticated-orcid":false,"given":"Nicholas J.","family":"Mercuro","sequence":"first","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital Detroit MI USA"},{"name":"Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MI USA"},{"name":"Department of Pharmacy Beth Israel Deaconess Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital Detroit MI USA"},{"name":"Center for Anti\u2010Infective Research and Development Hartford CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J.","family":"Alangaden","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-9486","authenticated-orcid":false,"given":"Susan L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital Detroit MI USA"},{"name":"Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Centers for Disease Control and Prevention.Drug resistance biggest threats.https:\/\/www.cdc.gov\/drugresistance\/biggest_threats.html. 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