{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:25:50Z","timestamp":1794248750726,"version":"4.9.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) infection is common among solid organ transplant (SOT) recipients and may cause CMV disease. To optimize the implementation of existing prevention strategies, the Management of Post\u2010transplant Infections in Collaborating Hospitals (MATCH) program was developed. Two key performances of MATCH (diagnosing CMV infection at low viral load (VL) and before the onset of CMV disease) were assessed prior to, during and after the implementation of MATCH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The MATCH program included a personalized surveillance plan, prophylaxis and preemptive therapy determined by the recipient's risk of CMV infection. The plan was composed through predefined algorithms and implemented through harvesting of real\u2010time data from medical records. Risk of CMV disease was compared for recipients transplanted during and after vs prior to the implementation of MATCH. Lung and non\u2010lung transplants were analyzed separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 593, 349, 520, and 360 SOT recipients were transplanted before (2007\u20102010), during (2011\u20102012), early after (2013\u20102015), and late after (2016\u20102017) implementation of MATCH with an observed reduction of diagnostic VL (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) over time. Risk of CMV disease was reduced among non\u2010lung transplant recipients transplanted during (adjusted hazard ratios [95% CI] 0.15 [0.04\u20100.54],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003), early after (aHR 0.27 [0.11\u20100.63],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003), and late after (aHR 0.17 [0.06\u20100.52],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) compared with prior to MATCH. No significant change was observed among lung transplants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implementation of CMV preventive strategies through MATCH was associated with a reduced risk of CMV disease among non\u2010lung transplant recipients. Furthermore, the limitations of VL as a sole indicator for CMV disease in lung transplants were emphasized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.13252","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T03:35:39Z","timestamp":1580355339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of an electronic, patient\u2010focused management system aimed at preventing cytomegalovirus disease following solid organ transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-4269","authenticated-orcid":false,"given":"Christina","family":"Ekenberg","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar","family":"da Cunha\u2010Bang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Hematology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle P.","family":"Lodding","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren S.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Sengel\u00f8v","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Perch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Section for Lung Transplantation Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neval E.","family":"Wareham","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Kirkby","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-1657","authenticated-orcid":false,"given":"Marie","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Reekie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Centre of Excellence for Health, Immunity and Infections (CHIP) Rigshospitalet University of Copenhagen Copenhagen 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