{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:28:39Z","timestamp":1774553319795,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201100041C"],"award-info":[{"award-number":["HHSN272201100041C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201600016C"],"award-info":[{"award-number":["HHSN272201600016C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201600019C"],"award-info":[{"award-number":["HHSN272201600019C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23 HL143050"],"award-info":[{"award-number":["K23 HL143050"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI118690\u201003"],"award-info":[{"award-number":["T32 AI118690\u201003"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few data support use of 6 over 3\u00a0months of antiviral prophylaxis for cytomegalovirus (CMV) disease prevention in donor seropositive\/recipient seronegative (D+R\u2212) heart transplant recipients (HTR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed CMV disease and outcomes in 310 adult HTR between July 5, 2005, and December 30, 2016, at our center. Valganciclovir (VGCV) prophylaxis was given for 3\u20106\u00a0months in the D+R\u2212 group. Multivariable models evaluated risk factors for CMV disease in patients who received 3 vs 6\u00a0months (\u00b11\u00a0month) of prophylaxis, with investigation of inverse probability weighting to correct for confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of CMV disease among all patients and the D+R\u2212 group was 8.7% (27\/310) and 26.5% (22\/83), respectively, and included syndrome in 22.2% (6\/27) and end\u2010organ involvement in 77.8% (21\/27). In a multivariable model, 6 vs 3\u00a0months of antiviral prophylaxis was not associated with reduced risk for CMV disease (OR 2.28 [95% CI 0.66, 7.91], <jats:italic>P\u00a0<\/jats:italic>=\u00a0.19). CMV disease in D+R\u2212 HTR was associated with higher rates of hospitalization (87.5% [14\/16] vs 6.3% [1\/16], <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001) and for a longer duration than in matched D+R\u2212 controls without disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytomegalovirus disease remains a major cause of morbidity in D+R\u2212 HTR. In contrast to documented benefit in D+R\u2212 lung and kidney recipients, VGCV duration of 6\u00a0months was not associated with a lower incidence of CMV disease in D+R\u2212 HTR compared to 3\u2010month duration and should be reconsidered in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13255","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:16:01Z","timestamp":1580894161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of valganciclovir prophylaxis duration on cytomegalovirus disease in high\u2010risk donor seropositive\/recipient seronegative heart transplant recipients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4655","authenticated-orcid":false,"given":"Hannah","family":"Imlay","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases Department of Medicine University of Washington Seattle Washington"},{"name":"Division of Infectious Diseases Department of Internal Medicine University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison O.","family":"Dumitriu Carcoana","sequence":"additional","affiliation":[{"name":"University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases Department of Medicine University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-8455","authenticated-orcid":false,"given":"Robert M.","family":"Rakita","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases Department of Medicine University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-9025","authenticated-orcid":false,"given":"Ajit P.","family":"Limaye","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases Department of Medicine University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"394","article-title":"Cytomegalovirus after heart transplantation. 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