{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:41:14Z","timestamp":1784266874365,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) infection is one of the major factors that affect morbidity and mortality in kidney transplant (KTx) patients. The rate of CMV seropositivity in children before KTx is lower than that in adults; therefore, pediatric KTx patients have a higher risk of CMV infection. In Japanese pediatric KTx patients, preemptive therapy for CMV infection is a main conventional therapy. This study investigated whether this preemptive treatment would affect kidney function at 2\u00a0years post\u2010KTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 163 patients, that is approximately half of the Japanese pediatric KTx patients nationwide, were recruited to participate in our study. We compared the values of the sequential estimated glomerular filtration rate (eGFR) at two years post\u2010KTx and other influencing factors in CMV viremia, CMV disease, and no\u2010infection groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytomegalovirus infection after KTx occurred in 75 patients (46.0%), 38.7% of whom developed CMV disease. The sequential eGFR values post\u2010KTx did not differ significantly between the three groups. CMV infection was not significantly correlated with other factors, other infections (including Epstein\u2010Barr [EB] virus infection), acute rejection (AR), or adverse events. Only prolonged duration of total hospitalization was significantly associated with CMV infection (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). In the multivariate analysis, younger age, CMV infection, and adverse effects were independently significantly related to prolonged total hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preemptive therapy for CMV infection evidenced by viremia and disease did not significantly influence kidney function in Japanese pediatric KTx patients at two years after the operation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13271","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T15:03:23Z","timestamp":1582902203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Kidney function of Japanese children undergoing kidney transplant with preemptive therapy for cytomegalovirus infection"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-361X","authenticated-orcid":false,"given":"Yoshimitsu","family":"Gotoh","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Japanese Red Cross Nagoya Daini Hospital Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Nephrology Toho University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Toho University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Watarai","sequence":"additional","affiliation":[{"name":"Department of Transplantation Surgery, Nephrology Japanese Red Cross Nagoya Daini Hospital Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kidney Center Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kidney Center Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonobu","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kidney Center Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aichi Children\u2019s Health and Medical Center Aichi 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