{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:47:13Z","timestamp":1781740033163,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Published literature on predictors of polyomavirus (BKV) and cytomegalovirus (CMV) infections in simultaneous pancreas and kidney (SPK) transplant and their impact on allograft outcomes remain sparse. We hypothesize that BKV and CMV viremia infections decrease allograft survival in SPK. Identifying modifiable predictors of BKV and CMV may help tailor immunosuppression and improve allograft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All SPK recipients at our institution between January 2000 and April 2016 were included (n\u00a0=\u00a0757). Thirty\u2010nine recipients had BKV only and 25 had CMV only, and infection occurred at median follow\u2010up times of 217 and 163\u00a0days, respectively. Event density sampling was used to match recipients with BKV or CMV to up to 10 recipients without infection by age, sex, and HLA mismatch status, and these were followed for a median of 4.3\u00a0years after infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older age (HR 1.49 for each decade; 95% CI: 0.95, 2.35; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.083) and tacrolimus use (HR 20.6; 95% CI: 2.37, 179.53; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) were associated with increased incidence of BKV, but not CMV, infection. Both BKV and CMV infections were associated with increased risk of allograft failure for both pancreas (BKV [HR 2.17; 95% CI 1.47, 3.208; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000], CMV [HR 1.7; 95% CI 1.077, 2.687; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023]) and kidney (BKV [HR 2.65; 95% CI 1.765, 3.984; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000], CMV [HR 2.07; 95% CI 1.295, 3.308; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Older age at time of transplant and tacrolimus may help predict BKV infection in SPK recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13272","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T17:39:57Z","timestamp":1582997997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polyomavirus and cytomegalovirus infections are risk factors for grafts loss in simultaneous pancreas and kidney transplant"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-5481","authenticated-orcid":false,"given":"Fahad","family":"Aziz","sequence":"first","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-9727","authenticated-orcid":false,"given":"Margaret R.","family":"Jorgenson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-1764","authenticated-orcid":false,"given":"Weixiong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis G.","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-6128","authenticated-orcid":false,"given":"Arjang","family":"Djamali","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"},{"name":"Division of Transplantation Department of Surgery University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-464X","authenticated-orcid":false,"given":"Jon","family":"Odorico","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-4963","authenticated-orcid":false,"given":"Hans","family":"Sollinger","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-0069","authenticated-orcid":false,"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"},{"name":"Department of Population Health Sciences University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-8407","authenticated-orcid":false,"given":"Maha A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.260"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2014.3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/597089"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819cc383"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14125"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000146"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm648"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200106270-00014"},{"key":"e_1_2_9_11_1","first-page":"47","article-title":"Pancreas transplantation in the United States (US) and non\u2010US as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR)","author":"Gruessner A","year":"1996","journal-title":"Clin Transpl"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.4.450"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.08.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00742.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu023"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181949629"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000228899.05501.a7"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"93","article-title":"Cytomegalovirus in solid organ transplantation","volume":"13","author":"Khubutiya MS","year":"2013","journal-title":"Am J Transplant"},{"issue":"4","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1681\/ASN.V124848","article-title":"Cytomegalovirus in renal transplantation","volume":"12","author":"Brennan DC","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00382.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2015(07)09"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.345"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1996.tb01635.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92887-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.04.010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00685.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200005150-00042"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12443"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017728296"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2126"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1333-1337.1998"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03670.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv441"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04320.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00140.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.271"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.12.8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/427690"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13252"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251721.90688.c2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2008.00344.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04076.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03693.x"},{"issue":"9","key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/TP.0b013e31823015c1","article-title":"Epidemiology of cytomegalovirus infection after pancreas transplantation","volume":"92","author":"Parsaik AK","year":"2011","journal-title":"Transplantation"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13272","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:46:10Z","timestamp":1693986370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/tid.13272"],"URL":"https:\/\/doi.org\/10.1111\/tid.13272","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2019-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13272"}}