{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:16:30Z","timestamp":1781950590052,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T00:00:00Z","timestamp":1586563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vancomycin\u2010resistant <jats:italic>Enterococcus<\/jats:italic> (VRE)\u2010colonized liver transplantation (LT) recipients have increased post\u2010LT morbidity, mortality, and higher rates of VRE infections compared with their non\u2010colonized counterparts. Pre\u2010LT screening for VRE colonization and inclusion of daptomycin in the perioperative antibiotic prophylaxis regimen may mitigate this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of liver transplant recipients aged\u00a0\u2265\u00a018\u00a0years between 2013 and August 2019 to identify pre\u2010LT VRE\u2010colonized recipients and whether they received daptomycin perioperative prophylaxis (DPP). Demographic and clinical characteristics, including risk factors for VRE infection, were collected. Outcomes measured were VRE\u2010related infection and all\u2010cause mortality within 90\u00a0days of LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 27 VRE\u2010colonized liver transplant recipients within the study period, 25 received DPP. All recipients were admitted to the intensive care unit postoperatively, six (24%) required reoperation, fifteen (60%) required renal replacement therapy, and eight (32%) experienced postoperative hemorrhage within 90\u00a0days post\u2010transplant. Two recipients (8%) experienced acute cellular rejection, but no primary graft failure was seen within 90\u00a0days. Among those who received DPP, no infections related to VRE or death was seen within 90\u00a0days of LT. The two VRE\u2010colonized recipients who did not receive DPP both developed VRE bacteremia in the early post\u2010LT period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite having multiple risk factors for post\u2010LT VRE infection, VRE\u2010colonized recipients who received DPP did not develop VRE\u2010related infections in the first 90\u00a0days post\u2010LT. Our experience demonstrates that pre\u2010LT VRE screening and DPP may be associated with a reduction in VRE infection in the early post\u2010LT period, but this strategy warrants further evaluation in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13280","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T08:04:05Z","timestamp":1585209845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Daptomycin perioperative prophylaxis for the prevention of vancomycin\u2010resistant <i>Enterococcus<\/i> infection in colonized liver transplant recipients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-3209","authenticated-orcid":false,"given":"Sajed","family":"Sarwar","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Koff","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-9994","authenticated-orcid":false,"given":"Maricar","family":"Malinis","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan M.","family":"Azar","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/amj.2017.12.10"},{"issue":"11","key":"e_1_2_6_3_1","first-page":"741","article-title":"Infectious complications after liver transplantation","volume":"11","author":"Hernandez MDP","year":"2015","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13589"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12690"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/498903"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02304.x"},{"key":"e_1_2_6_8_1","volume-title":"Antibiotic Resistance Threats in the United States, 2019","author":"CDC","year":"2019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12784"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12523"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12856"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181735407"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500030602"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21435"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00083-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12099"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2015.09.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13004"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:47:36Z","timestamp":1693986456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,11]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/tid.13280"],"URL":"https:\/\/doi.org\/10.1111\/tid.13280","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,11]]},"assertion":[{"value":"2019-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13280"}}