{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:25:14Z","timestamp":1763457914851,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long\u2010term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36\u2010year\u2010old kidney\u2010transplanted woman affected by Senior\u2010Loken syndrome diagnosed with COVID\u201019 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough, and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir\/ritonavir were started, and the antiviral drug was replaced with darunavir\/cobicistat after 2\u00a0days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case report. We stress the need for guidelines in transplant recipients with COVID\u201019 infection with particular regard to the management of therapy.<\/jats:p>","DOI":"10.1111\/tid.13286","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T20:46:43Z","timestamp":1586724403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Threatening drug\u2010drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID\u201019)"],"prefix":"10.1111","volume":"22","author":[{"given":"Maril\u00f9","family":"Bartiromo","sequence":"first","affiliation":[{"name":"Nephrology Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-5225","authenticated-orcid":false,"given":"Beatrice","family":"Borchi","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-1211","authenticated-orcid":false,"given":"Annarita","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Bagal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6626-3258","authenticated-orcid":false,"given":"Gianmarco","family":"Lugli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tilli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunilda","family":"Xhaferi","sequence":"additional","affiliation":[{"name":"Nephrology Unit University of Milan\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Cutruzzul\u00e0","sequence":"additional","affiliation":[{"name":"Nephrology Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Vaglio","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Experimental and clinical Sciences \u201cMario Serio\u201d University of Florence Florence Italy"},{"name":"Nephrology and Dialysis Unit Meyer Children\u2019s Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bresci","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Larti","sequence":"additional","affiliation":[{"name":"Nephrology Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bartoloni","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Careggi University Hospital Florence Italy"},{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Cirami","sequence":"additional","affiliation":[{"name":"Nephrology Unit Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25699"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15832"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00197.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13085"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15869"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15874"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"issue":"18","key":"e_1_2_5_10_1","first-page":"20023242","article-title":"Kidney impairment is associated with in\u2010hospital death of COVID\u201019 patients","volume":"02","author":"Cheng 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