{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:37:18Z","timestamp":1776915438569,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010455","name":"Swiss Transplant Cohort Study","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33CS30_134267"],"award-info":[{"award-number":["33CS30_134267"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33CS30_148512"],"award-info":[{"award-number":["33CS30_148512"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infections are an important complication after allogeneic hematopoietic cell transplantation (allo\u2010HCT). The present study aimed at determining the landscape of infections occurring in a large cohort of allo\u2010HCT patients, as well as associated risk factors for infections and for one\u2010year non\u2010relapse mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study using STCS and EBMT databases to assess the one\u2010year incidence rate of infection, as well as risk factors for infections and for one\u2010year non\u2010relapse mortality among adult allo\u2010HCT patients transplanted between 2010 and 2014 in Switzerland. Univariable and multivariable quasi\u2010Poisson and multivariable Cox regression models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 553 patients included, 486 had an infection with a global incidence rate of 3.66 infections per patient\u2010year. Among a total of 1534 infections analyzed, viral infections were predominant (n\u00a0=\u00a01138, 74.2%), followed by bacterial (n\u00a0=\u00a0343, 22.4%) and fungal (n\u00a0=\u00a053, 3.5%) infections. At one year, the cumulative incidence of relapse and non\u2010relapse mortality was 26% and 16%, respectively. 195 (35.3%) of patients had at least one episode of severe graft\u2010versus\u2010host\u2010disease (GvHD). A center effect was observed, and underlying disease, donor type, cytomegalovirus serological constellation, and GvHD were also associated with the incidence rate of infections. There was an increased risk for one\u2010year non\u2010relapse mortality associated with all pathogens, specifically within two months of infection, and this remained true beyond 2\u00a0months of a fungal infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite advances to limit infections in this population, they still occur in most allo\u2010HCT patients with a major impact on survival at 1\u00a0year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13289","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T18:59:30Z","timestamp":1586631570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5\u2010year analysis within the Swiss Transplant Cohort 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