{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:33:19Z","timestamp":1776331999042,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 20\u2010year\u2010old male presented 3.5\u00a0years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was consistent with inflammation and\/or demyelination. Lumbar puncture was initially non\u2010diagnostic and a broad infectious workup was unrevealing. Three months after presentation, a repeat LP detected JC virus for which tests had not earlier been conducted. He continued to deteriorate despite withdrawal of prior immunosuppression and addition of mirtazapine, maraviroc, and steroids. He died of progressive neurologic decompensation 5\u00a0months after his initial presentation. This case highlights progressive multifocal leukoencephalopathy (PML) as a rare complication after solid organ transplantation and acute sensorineural hearing loss as an unusual first presenting symptom of PML. JC virus should be considered in the differential diagnosis of acute sensorineural hearing loss in any immunocompromised patient.<\/jats:p>","DOI":"10.1111\/tid.13304","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:11:29Z","timestamp":1588651889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-1611","authenticated-orcid":false,"given":"Andrew M.","family":"Lippa","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-1634","authenticated-orcid":false,"given":"Karen E.","family":"Ocwieja","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Fawaz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Yale New Haven Children\u2019s Hospital New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-287X","authenticated-orcid":false,"given":"Scott","family":"Elisofon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91777-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24371"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/597126"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10450"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"179","article-title":"John Cunningham virus: an overview on biology and disease of the etiological agent of the progressive multifocal leukoencephalopathy","volume":"41","author":"Pietropaolo V","year":"2018","journal-title":"New Microbiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5537"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00609-10"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.06.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.06.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.3.485"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/926391"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.06.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21710"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02472-08"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/466532"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01139.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01464.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22408"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.11.002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.557"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511421919"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.301"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2fa1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31818b62c8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f73600"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490270405"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550280009013156"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/653823"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12128"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1018"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/823710"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7234-3658-4.00018-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13548"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12554"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01614-08"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0433-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830a5043"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.221"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801540"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-304897"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-019-00769-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343510.08643.74"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25070"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1304828"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000331"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00800.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01368.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00804-5"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13162"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12107"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12080"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T18:01:20Z","timestamp":1693677680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/tid.13304"],"URL":"https:\/\/doi.org\/10.1111\/tid.13304","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13304"}}