{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:11:20Z","timestamp":1789603880975,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human herpesvirus\u20106 (HHV\u20106) is a common pathogen affecting the human population. Primary HHV\u20106 infection generally occurs during infancy and causes exanthema subitum. Moreover, HHV\u20106 may exhibit inherited chromosomally integrated HHV\u20106 (iciHHV\u20106) in certain individuals. Although iciHHV\u20106 is generally known to be nonpathogenic, it may cause reactivation in patients with primary immunodeficiency disease (PID). XIAP deficiency is a rare PID characterized by recurrent hemophagocytic lymphohistiocytosis (HLH). It has been reported that the Epstein\u2010Barr virus primarily causes HLH; however, the other pathogens, including HHV\u20106, can also cause this complication. We encountered a case of XIAP deficiency accompanied by iciHHV\u20106. He suffered from recurrent HLH, for which allogeneic bone marrow transplantation (BMT) was performed as a curative therapy. During the course of BMT, the patient experienced HLH three times, but there was no reactivation of endogenous HHV\u20106 from iciHHV\u20106. Finally, the patient achieved complete donor chimerism and a decline in HHV\u20106 DNA copy number in whole blood. This case report demonstrates no evidence of reactivation of iciHHV\u20106 during BMT in a patient with XIAP deficiency.<\/jats:p>","DOI":"10.1111\/tid.13331","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:29:18Z","timestamp":1589869758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inherited chromosomally integrated human herpesvirus\u20106 in a patient with XIAP deficiency"],"prefix":"10.1111","volume":"22","author":[{"given":"Kento","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-3374","authenticated-orcid":false,"given":"Hiroki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department 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