{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:40:34Z","timestamp":1770885634327,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The burden of urinary tract infections (UTIs) and risk factors for developing infections with multidrug resistant organisms (MDROs) post\u2010kidney transplantation (KT) are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center retrospective cohort study (January 2015\u2010December 2017) evaluating first and recurrent episodes of bacteriuria and subsequent analysis of episodes caused by MDROs up to 6\u00a0months post\u2010KT. Donor and recipient variables were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 743 adults underwent single KT during the study period, and 106 patients were hospitalized with bacteriuria. 45% were asymptomatic in their first episode. 73.6% had a single episode, and 26.4% had 2 or more episodes. A total of 28 patients had recurrent episodes; 64.3% had an MDRO on the first episode and 78.6% on the second episode. <jats:italic>Escherichia coli<\/jats:italic> was the most common organism isolated, 88.5% were resistant to trimethoprim\u2010sulfamethoxazole (TMP\u2010SMX), 9.3% were extended\u2010spectrum beta\u2010lactamase (ESBL) producers, and 38.1% were MDROs. Body mass index \u226530 was significantly associated with the presence of MDROs in both univariate and multivariate analyses (RR 1.37, 95% CI 1.01\u20101.88; OR 3.26, CI 1.29\u20108.25). A total of 12 donors had bacteremia or bacteriuria and 6 (50%) with <jats:italic>E\u00a0coli<\/jats:italic>. A total of 10 KT recipients received antibiotic prophylaxis to prevent donor\u2010derived infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that a significant proportion of patients develop recurrent bacteriuria post\u2010transplantation; of those, more than half caused by MDROs. There is a possible association between obesity and MDROs in KT recipients that merits further investigation. With the global crisis in antimicrobial resistance, innovative strategies are needed to prevent and treat UTIs in KT patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13337","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:49:51Z","timestamp":1590482991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antimicrobial resistance and recurrent bacterial urinary tract infections in hospitalized patients following kidney transplantation: A single\u2010center experience"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-4590","authenticated-orcid":false,"given":"Samantha","family":"Greissman","sequence":"first","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Mattiazzi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Medicine Jackson Memorial Hospital Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-125X","authenticated-orcid":false,"given":"Yoichiro","family":"Natori","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Grady","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Quinonez","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"},{"name":"Department of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Zukerman","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-5011","authenticated-orcid":false,"given":"Jose F.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9626-0760","authenticated-orcid":false,"given":"Jacques","family":"Simkins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Guerra","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian M.","family":"Abbo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Miami Transplant Institute University of Miami Miller School of Medicine Miami FL USA"},{"name":"Department of Infection Control and Prevention Jackson Health System Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000296"},{"key":"e_1_2_8_3_1","unstructured":"CDC.NHSN Urinary Tract Infection (UTI) Checklist. 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