{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:08:31Z","timestamp":1787062111457,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study is to determine the incidence, etiology, clinical characteristics, and outcomes of renal transplant recipients diagnosed and treated for central nervous system (CNS) infection at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from all renal transplant recipients between January 2007 and December 2019 that were diagnosed and treated for CNS infections at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1374 patients who received renal allografts, 13 were diagnosed with CNS infections (9 males), with a mean age of 53.5\u00a0years. Patients were diagnosed with CNS infections between 2\u00a0months and 11\u00a0years after the transplantation. Causative agents included\n                      <jats:italic>JC virus<\/jats:italic>\n                      ,\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      ,\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                      ,\n                      <jats:italic>Herpes zoster virus<\/jats:italic>\n                      ,\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      ,\n                      <jats:italic>Listeria monocytogenes,<\/jats:italic>\n                      and\n                      <jats:italic>West Nile virus<\/jats:italic>\n                      . One patient had concomitant\n                      <jats:italic>Nocardia<\/jats:italic>\n                      and\n                      <jats:italic>Neisseria<\/jats:italic>\n                      infection. Immunosuppression was reduced in all patients. The patient with\n                      <jats:italic>JC<\/jats:italic>\n                      encephalitis and the patient with concomitant\n                      <jats:italic>Neisseria<\/jats:italic>\n                      and\n                      <jats:italic>Nocardia<\/jats:italic>\n                      meningitis died. One patient was returned to dialysis. Other patients recovered with differing levels of neurologic sequelae.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Central nervous system infections in renal transplant recipients are rare. However, they are associated with significant morbidity and mortality. A high level of awareness is needed: neurological symptoms may be nonspecific and caused by non\u2010infectious conditions related to the underlying disease, or side\u2010effects of immunosuppressive drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.13341","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:39:13Z","timestamp":1590503953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Central nervous system infections in renal transplant recipients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-2758","authenticated-orcid":false,"given":"Nikolina","family":"Basic\u2010Jukic","sequence":"first","affiliation":[{"name":"Department of Nephrology Arterial Hypertension, Dialysis and Transplantation University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Department of Urology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Faculty of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Juric","sequence":"additional","affiliation":[{"name":"Department of Nephrology Arterial Hypertension, Dialysis and Transplantation University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Department of Urology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Faculty of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Furic\u2010Cunko","sequence":"additional","affiliation":[{"name":"Department of Nephrology Arterial Hypertension, Dialysis and Transplantation University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Department of Urology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"Faculty of Medicine University of Zagreb Zagreb 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