{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:38Z","timestamp":1753879358581,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hepatitis C virus mainly infects the liver but is also able to infect and replicate in other body compartments by creating an extra\u2010hepatic reservoir that may influence the persistence of the infection after transplantation. It is unknown whether antiviral drugs affect the viral extra\u2010hepatic sites. We evaluated the ability of pegylated\/interferon\u00a0+\u00a0ribavirin and sofosbuvir\u00a0+\u00a0ribavirin to clear the virus from the gastrointestinal mucosa of liver\u2010transplanted patients with HCV recurrence after transplantation.<\/jats:p><jats:p>A total of 51 liver\u2010transplanted patients, 30 treated with pegylated\/interferon\u00a0+\u00a0ribavirin (ERA1) and 21 treated with sofosbuvir\u00a0+\u00a0ribavirin (ERA2), were enrolled, and blood serum and gastrointestinal tissues analyzed for the presence of HCV\u2010RNA.<\/jats:p><jats:p>In the ERA1 group, the 46.6% of patients had a sustained viral response to antiviral treatment, and gastrointestinal biopsies were positive for HCV in 73.3% of cases, 54.5% of responders, and 45.5% of non\u2010responders. In the ERA2 group, the 66.6% had a sustained viral response, and gastrointestinal HCV\u2010RNA was present in the 14.3% of patients, all relapsers. Sofosbuvir\u00a0+\u00a0ribavirin cleared the intestinal HCV in 85.7% of patients with recurrent HCV infection, while pegylated\/interferon\u00a0+\u00a0ribavirin cleared it in 26.6% of treated patients, demonstrating the better effectiveness of new direct antiviral agents in clearing HCV intestinal reservoir.<\/jats:p>","DOI":"10.1111\/tid.13345","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T11:55:26Z","timestamp":1591271726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Direct\u2010acting antivirals ability to clear intestinal HCV\u2010RNA in liver transplant patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Giada","family":"Pietrosi","sequence":"first","affiliation":[{"name":"Hepatology Unit Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation IRCCS ISMETT Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-0892","authenticated-orcid":false,"given":"Giovanna","family":"Russelli","sequence":"additional","affiliation":[{"name":"Department of Research IRCCS ISMETT Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Barbera","sequence":"additional","affiliation":[{"name":"Department of Research IRCCS ISMETT Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Curcio","sequence":"additional","affiliation":[{"name":"Endoscopy Service Department of Diagnostic and Therapeutic Services IRCCS ISMETT Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tuzzolino","sequence":"additional","affiliation":[{"name":"Department of Research IRCCS ISMETT Palermo 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