{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:56:08Z","timestamp":1784566568944,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pyogenic liver abscesses in liver transplant recipients (PLA\u2010LTR) are a rare disease whose specificities compared with PLA in non\u2010transplanted patients (PLA\u2010C) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2010control study was conducted in a French academic hospital from January 1, 2010, to December 31, 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 176 patients diagnosed with PLA, 14 were LTR; each case was matched with 3 PLA\u2010C controls by date of PLA diagnosis and pathophysiological mechanism of PLA. Median time from liver transplantation to PLA diagnosis was 34.5\u00a0months. Among 14 PLA\u2010LTR, 8\/14 (57.1%) had bacteremia and 10\/14 (71.4%) had positive PLA cultures. Most commonly isolated bacteria were <jats:italic>Enterobacteriaceae<\/jats:italic> (9\/14; 64.3%), <jats:italic>Enterococcus<\/jats:italic> spp. (4\/14; 28.6%), and anaerobic bacteria (3\/14; 21.4%). Clinical, radiological, and microbiological characteristics did not significantly differ between PLA\u2010LTR and PLA\u2010C but there was a tendency toward more diabetic patients and a less acute presentation. All but one PLA\u2010LTR were associated with ischemic cholangitis, whereas this was a rare cause among PLA\u2010C (13\/14 vs 3\/42, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) among patients with PLA\u2010LTR. In contrast, hepatobiliary neoplasia was rare in PLA\u2010LTR but frequent in PLA\u2010C (1\/14 vs 24\/42, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). No significant difference was found between PLA\u2010LTR and PLA\u2010C in terms of duration of antibiotic therapy (6.5 and 6\u00a0weeks, respectively), PLA drainage rates (10\/14 and 26\/42, respectively), or mortality at 12\u00a0months after PLA diagnosis (2\/14 and 5\/42, respectively). Recurrence rates within the first year were observed in 6\/14 patients (42.9%), and retransplantation was needed in 5\/14 (35.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occurrence of PLA in LTR is a severe event leading to high risk of recurrence and retransplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13360","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T13:26:23Z","timestamp":1591709183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pyogenic liver abscess in liver transplant recipient: A warning signal for the risk of recurrence and retransplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-4285","authenticated-orcid":false,"given":"Emmanuel","family":"Lafont","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne H\u00f4pital Beaujon Assistance 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