{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:41:24Z","timestamp":1760647284599,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical course and outcomes of immunocompromised patients, such as transplant recipients, with COVID\u201019 remain unclear. It has been postulated that a substantial portion of the disease burden seems to be mediated by the host immune activation to the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). Herein, we present a simultaneous heart\u2010kidney transplant (SHKT) recipient who was hospitalized for the management of respiratory failure from volume overload complicated by failure to thrive, multiple opportunistic infections, and open non\u2010healing wounds in the setting of worsening renal dysfunction weeks prior to the first case of SARS\u2010CoV\u20102 being detected in the state of Connecticut. After his third endotracheal intubation, routine nucleic acid testing (NAT) for SARS\u2010CoV\u20102, in anticipation of a planned tracheostomy, was positive. His hemodynamics, respiratory status, and ventilator requirements remained stable without any worsening for 4\u00a0weeks until he had a negative NAT test. It is possible that the immunocompromised status of our patient may have prevented significant immune activation leading up to clinically significant cytokine storm that could have resulted in acute respiratory distress syndrome and multisystem organ failure.<\/jats:p>","DOI":"10.1111\/tid.13367","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T08:51:00Z","timestamp":1592038260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidental COVID\u201019 in a heart\u2010kidney transplant recipient with malnutrition and recurrent infections: Implications for the SARS\u2010CoV\u20102 immune response"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5076-0938","authenticated-orcid":false,"given":"Oscar K.","family":"Serrano","sequence":"first","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Department of Surgery University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0106-9822","authenticated-orcid":false,"given":"Heather L.","family":"Kutzler","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Rochon","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Department of Surgery University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Radojevic","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Center for Advanced Heart Failure and Pulmonary Vascular Disease Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Lawlor","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Center for Advanced Heart Failure and Pulmonary Vascular Disease Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Gluck","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Center for Advanced Heart Failure and Pulmonary Vascular Disease Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Feingold","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Center for Advanced Heart Failure and Pulmonary Vascular Disease Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Hartford Hospital Transplant &amp; Comprehensive Liver Center Hartford Connecticut USA"},{"name":"Center for Advanced Heart Failure and Pulmonary Vascular Disease Hartford Hospital Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105954"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2011117"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"COVID\u201019 in solid organ transplant recipients: initial report from the US epicenter","author":"Pereira MR","year":"2020","journal-title":"Am J Transplant"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15929"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13528"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.01.190"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182247b5f"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15936"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.053"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.11.008"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:09:12Z","timestamp":1693764552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/tid.13367"],"URL":"https:\/\/doi.org\/10.1111\/tid.13367","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13367"}}