{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:25:54Z","timestamp":1762899954120,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Which are the consequences of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in liver transplant (LT) recipients?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We attempted to address this question by reviewing our single\u2010center experience during the first 2\u00a0months of the pandemics at a high incidence area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen adult patients (5 females) were diagnosed by May 5, 2020. Median age was 58 (range 55\u201072), and median follow\u2010up since transplantation was 83 (range 20\u2010183) months. Cough (84.2%), fever (57.9%), and dyspnea (47.4%) were the most common symptoms. Thirteen patients (68.4%) had pneumonia in x\u2010ray\/CT scan. Hydroxychloroquine was administered in 11 patients, associated with lopinavir\/ritonavir and interferon \u03b2 in 2 cases each. Immunomodulatory therapy with tocilizumab was used in 2 patients. Immunosuppression (IS) was halted in one patient and modified in only other two due to potential drug interactions. Five (26.3%) patients were managed as outpatient. Two patients (10.5%) died, 10 (52.6%) were discharged home, and 2 (10.5%) were still hospitalized after a median follow\u2010up of 41\u00a0days from the onset of symptoms. Baseline IS regimen remained unchanged in all surviving recipients, with good liver function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our preliminary experience shows a broad spectrum of disease severity in LT patients with COVID\u201019, with a favorable outcome in most of them without needing to modify baseline IS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13372","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T20:00:55Z","timestamp":1592683255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Varied clinical presentation and outcome of SARS\u2010CoV\u20102 infection in liver transplant recipients: Initial experience at a single center in Madrid, Spain"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-0568","authenticated-orcid":false,"given":"Carmelo","family":"Loinaz","sequence":"first","affiliation":[{"name":"HBP and Transplant Surgery Unit Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Marcacuzco","sequence":"additional","affiliation":[{"name":"HBP and Transplant Surgery Unit Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Unit of infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Caso","sequence":"additional","affiliation":[{"name":"HBP and Transplant Surgery Unit Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Cambra","sequence":"additional","affiliation":[{"name":"HBP and Transplant Surgery Unit Department 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