{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:34:46Z","timestamp":1777530886255,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infection related to Coronavirus\u201019 (CoV\u20102) is pandemic affecting more than 4 million people in 187 countries worldwide. By May 10, 2020, it caused more than 280\u00a0000 deaths all over the world. Preliminary data reported a high prevalence of CoV\u20102 infection and mortality due to severe acute respiratory syndrome related CoV\u20102 (SARS\u2010CoV\u20102) in kidney\u2010transplanted patients (KTRs). Nevertheless, the outcomes and the best treatments for SARS\u2010CoV\u20102\u2010affected KTRs remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this report, we describe the clinical data, the treatments, and the outcomes of 5 KTRs with SARS\u2010CoV\u20102 admitted to our hospital in Ancona, Marche region, Italy, from March 17 to present. Due to the severity of SARS\u2010CoV\u20102, immunosuppression with calcineurin inhibitors, antimetabolites, and mTOR\u2010inhibitors were stopped at the admission. All KTRs were treated with low\u2010dose steroids. 4\/5 KTRs were treated with hydroxychloroquine. All KTRs received tocilizumab up to one dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the incidence of SARS\u2010CoV\u20102 in KTRs in the Marche region was 0.85%. 3\/5 were admitted in ICU and intubated. One developed AKI with the need of CRRT with Cytosorb. At present, two patients died, two patients were discharged, and one is still inpatient in ICU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The critical evaluation of all cases suggests that the timing of the administration of tocilizumab, an interleukin\u20106 receptor antagonist, could be associated with a better efficacy when administered in concomitance to the drop of the oxygen saturation. Thus, in SARS\u2010CoV\u20102\u2010affected KTRs, a close biochemical and clinical monitoring should be set up to allow physicians to hit the virus in the right moment such as a sudden reduction of the oxygen saturation and\/or a significant increase in the laboratory values such as D\u2010dimer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13377","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T16:31:47Z","timestamp":1592929907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["SARS\u2010CoV\u20102 infection in kidney transplant recipients: Experience of the italian marche region"],"prefix":"10.1111","volume":"22","author":[{"given":"Federica","family":"Maritati","sequence":"first","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplantation Unit Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto I Lancisi Salesi of Ancona Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Anesthesia and Transplant Surgical Intensive Care Unit Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zuccatosta","sequence":"additional","affiliation":[{"name":"Operative Unit of Pneumology Ospedali Riuniti University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Fiorentini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic Department of Biological Sciences and Public Health Marche Polytechnic University Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Finale","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplantation Unit Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto I Lancisi Salesi of Ancona Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ficosecco","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy"},{"name":"Department of Biomedical Sciences and Public Health Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Italian Civil Protection Department for Covid\u201019 Emergency Nephrology and Dialysis Unit Ospedale \"San Pio da Pietrelcina\" Vasto Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Capestro","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Congenital Cardiac Surgery and Cardiology Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Balestra","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplantation Unit Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto I Lancisi Salesi of Ancona Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenica","family":"Taruscia","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplantation Unit Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto I Lancisi Salesi of Ancona Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vivarelli","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abele","family":"Donati","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy"},{"name":"Department of Biomedical Sciences and Public Health Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Piero","family":"Perna","sequence":"additional","affiliation":[{"name":"Cardiovascular Science Department, Cardiology and Coronary Care Unit Ospedali Riuniti di Ancona Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Giacometti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic Department of Biological Sciences and Public Health Marche Polytechnic University Ancona 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