{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:35:06Z","timestamp":1782455706534,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17fm0208015"],"award-info":[{"award-number":["JP17fm0208015"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated the clinical impact of cytomegalovirus (CMV) reactivation calculated in terms of the area under the curve of CMV antigenemia (CMV\u2010AUC) on the development of invasive mold infection (IMI) in the post\u2010engraftment phase after allogeneic hematopoietic stem cell transplantation (HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 394 consecutive patients who underwent their first allogeneic HSCT at our center between 2007 and 2018, 335 were included after excluding patients with a past history of invasive fungal disease (IFD), the development of IFD before engraftment, engraftment failure, or early death within 30\u00a0days. CMV antigenemia (CMV\u2010AG) was monitored weekly after engraftment and 3 or more cells\/2 slides were regarded as positive. CMV\u2010AUC was calculated by the trapezoidal method using the number of CMV\u2010AG after logarithmic transformation and the duration in weeks and was added until negative conversion. Patients with CMV reactivation were divided into low and high CMV\u2010AUC groups using the median value of CMV\u2010AUC as a threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 17 proven\/probable IMIs including one mucormycosis and 16 probable invasive aspergillosis, and the 2\u2010year cumulative incidence was 1.0% in the negative CMV\u2010AUC group (n\u00a0=\u00a0136), 3.3% in the low CMV\u2010AUC group (n\u00a0=\u00a098) and 13.8% in the high CMV\u2010AUC group (n\u00a0=\u00a0101) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). In a multivariate analysis, grade II\u2010IV acute GVHD (HR 3.74) and CMV\u2010AUC (HR low 1.25, high 5.91) were identified as independent significant factors associated with a higher incidence of IMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytomegalovirus kinetics evaluated in terms of CMV\u2010AUC were significantly associated with the development of IMI in the post\u2010engraftment phase after allogeneic HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13387","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T21:51:58Z","timestamp":1593121918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between the kinetics of cytomegalovirus reactivation evaluated in terms of the area under the curve of cytomegalovirus antigenemia and invasive mold infection during the post\u2010engraftment phase after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-8526","authenticated-orcid":false,"given":"Shun\u2010ichi","family":"Kimura","sequence":"first","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunto","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4366-315X","authenticated-orcid":false,"given":"Yukiko","family":"Misaki","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Matsumi","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Gomyo","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-9340","authenticated-orcid":false,"given":"Yu","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Kusuda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Kameda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriko","family":"Terasako\u2010Saito","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Tanihara","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nakasone","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kako","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/595846"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/651263"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1496"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0456"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/591969"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.39"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.623311"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.06.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.07.025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23735"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2015.01.002"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"78","article-title":"Risk factors for the development of cytomegalovirus disease after allogeneic stem cell transplantation","volume":"91","author":"Ljungman P","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13049"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix804"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.337"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.213"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13204"},{"issue":"6","key":"e_1_2_8_21_1","first-page":"825","article-title":"Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"e_1_2_8_22_1","first-page":"545","article-title":"Chronic cutaneous graft\u2010versus\u2010host disease in man","volume":"91","author":"Shulman HM","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3141-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3385-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0365-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12118"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.09.020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702805"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202270-00015"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073754"},{"issue":"3","key":"e_1_2_8_31_1","first-page":"1750","article-title":"CMV antigenemia assay using indirect ALP\u2010immunostaining in bone marrow transplant recipients","volume":"28","author":"Kurihara T","year":"1996","journal-title":"Transplant Proc"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.02.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.178"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0161-1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000502"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.477"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02824.x"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T05:28:02Z","timestamp":1693805282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/tid.13387"],"URL":"https:\/\/doi.org\/10.1111\/tid.13387","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"2020-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13387"}}