{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:43:34Z","timestamp":1791996214111,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In transplant recipients, cytomegalovirus (CMV) infection increases morbidity and mortality; furthermore, coinfection with other human herpesviruses like the Epstein\u2010Barr virus (EBV) may complicate their management. This systematic literature review aimed to summarize rates of CMV\u2010EBV coinfection and associated clinical outcomes among solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic literature search was performed using pre\u2010specified search strategies (January 1, 2010\u2010October 31, 2018) and following established\/best practice methodology. Of 316 publications identified, 294 did not report CMV\u2010EBV coinfection and were excluded. Studies meeting the inclusion criteria were further analyzed. Due to limited reporting\/heterogeneity, data were not meta\u2010analyzable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies (six SOT; three HSCT) reported CMV\u2010EBV coinfection; rates of coinfection post transplantation varied between 2.6% and 32.7%. Two studies indicated CMV reactivation to be an independent variable associated with EBV reactivation. Among SOT studies, higher rates of graft dysfunction (47.4% vs 22.9%), rejection episodes (20.0% vs 8.9%), or acute rejection (50.0% vs 31.0%) were reported for patients with coinfection than without. In HSCT studies, patients with graft\u2010vs\u2010host disease were not reported separately for coinfection. Two studies described cases of post\u2010transplant lymphoproliferative disorder (PTLD) in patients with CMV\u2010EBV coinfection and reported rates of PTLD of 92% and 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CMV\u2010EBV coinfection rate in HSCT and SOT recipients varied and was associated with increased graft rejection and PTLD compared with patients without coinfection. Further research may improve understanding of the burden of CMV\u2010EBV coinfection among transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13396","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T21:40:43Z","timestamp":1593553243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Coinfection rates and clinical outcome data for cytomegalovirus and Epstein\u2010Barr virus in post\u2010transplant patients: A systematic review of the literature"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-6154","authenticated-orcid":false,"given":"Colin","family":"Anderson\u2010Smits","sequence":"first","affiliation":[{"name":"Shire, A Takeda Company Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin R.","family":"Baker","sequence":"additional","affiliation":[{"name":"CTI Clinical Trial &amp; 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