{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:45:44Z","timestamp":1753879544281,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Cutibacterium (C) acnes<\/jats:italic>, a Gram\u2010positive bacterium that is part of the commensal flora, is increasingly noticed as an opportunistic pathogen in serious infections in both immunocompromised and immunocompetent patients. The indolent character and often difficult identification because of its slow growth contribute to delayed diagnosis or underdiagnosis. This report highlights a unique case of a lung transplant recipient with a <jats:italic>C\u00a0acnes<\/jats:italic> intracerebral abscess, and we recommend including this organism in such differential diagnosis. A 66\u2010year\u2010old woman, 2\u00a0years after bilateral lung transplantation for chronic obstructive pulmonary disease, presented with frontal headache, without other complaints, and with normal neurological examination. Magnetic resonance imaging showed an extensive lesion in the right frontal lobe with extensive perilesional edema. Given the broad differential diagnosis, stereotactic brain biopsy was performed and culture became positive for <jats:italic>C\u00a0acnes<\/jats:italic>. She was treated with intravenous ceftriaxone for 8\u00a0weeks and per oral clindamycin for 6\u00a0months, as well as corticosteroids in tapered dose. There was a rapid favorable clinical and radiographic evolution.<\/jats:p>","DOI":"10.1111\/tid.13398","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T17:29:33Z","timestamp":1593624573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intracerebral abscess due to Cutibacterium acnes after lung transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-5914","authenticated-orcid":false,"given":"Saskia","family":"Bos","sequence":"first","affiliation":[{"name":"Department of Respiratory Disease University Hospital Gasthuisberg UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"De Vleeschouwer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital Gasthuisberg UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk E.","family":"Van Raemdonck","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery University Hospital Gasthuisberg UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert M.","family":"Verleden","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease University Hospital Gasthuisberg UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-9251","authenticated-orcid":false,"given":"Robin","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease University Hospital Gasthuisberg UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"477","article-title":"Severe infections caused by Propionibacterium acnes: an underestimated pathogen in late postoperative infections","volume":"69","author":"Jakab E","year":"1996","journal-title":"Yale J Biol Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm351"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690310001601225"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/518580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1404452"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2017.05.030"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.2015.1017438"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2298"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200106000-00015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.75"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.09.038"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"60","article-title":"Abscess formation within cerebellar metastatic carcinoma\u2013report of two cases and review of the literature","volume":"116","author":"Kovacic S","year":"2004","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2009.45.1.53"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-212431"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/313627"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12512"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:08:59Z","timestamp":1693688939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/tid.13398"],"URL":"https:\/\/doi.org\/10.1111\/tid.13398","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2020,7,14]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13398"}}