{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:41:24Z","timestamp":1768282884232,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Graft\u2010versus\u2010host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T\u2010cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in severe COVID\u201019 cases appears to be related to a massive production of pro\u2010inflammatory cytokines. The selective JAK1\/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID\u201019; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. We describe a first case of severe COVID\u201019 developed after hematopoietic stem cell transplantation in a patient with a concomitant chronic GVHD (cGVHD), in which a treatment with ruxolitinib was administered with good tolerance and positive outcome.<\/jats:p>","DOI":"10.1111\/tid.13401","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T21:32:51Z","timestamp":1594071171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Severe COVID\u201019 in a patient with chronic graft\u2010versus\u2010host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-9514","authenticated-orcid":false,"given":"Francesco","family":"Saraceni","sequence":"first","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Scortechini","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Mancini","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Mariani","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Federici","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Gaetani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Covid\u201019 Hospital Civitanova Marche Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Barbatelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Covid\u201019 Hospital Civitanova Marche Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Minnucci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Covid\u201019 Hospital Civitanova Marche Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Bagnarelli","sequence":"additional","affiliation":[{"name":"Institute of Virology Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Ancona University Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200391"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13940-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa237"},{"key":"e_1_2_9_6_1","unstructured":"https:\/\/www.fda.gov\/media\/134922\/download. 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