{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:10:18Z","timestamp":1780319418464,"version":"3.54.1"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review addresses relevant aspects of Chagas disease in the solid organ transplantation setting. This trypanosomiasis was geographically restricted to America, but migration has turned Chagas disease into a global public health concern. Parasite persistence in chronically infected individuals entails the potential of transmission with organ donation and the potential for reactivation under immunosuppression. Prospective monitoring with real\u2010time PCR or direct methods for detection of parasitemia and treatment of documented episodes of transmission\/ reactivation (rather than prophylactic treatment) is the recommended approach for managing patients at risk. Chagas disease is an important cause of terminal cardiomyopathy. Clinical results demonstrate that with adequate monitoring and treatment, patients with Chagas cardiomyopathy benefit from heart transplantation, with long\u2010term results even better than patients who underwent heart transplantation due to other conditions. Kidney and liver (and possibly other solid organs) transplantation can be safely performed in chronically infected patients with adequate management. Chronically infected patients are also suitable for organ donation (with the exception of the heart and intestines). Although reactivations and transmissions are observed, serious clinical disease is rare, and they are usually successfully managed with benznidazole or nifurtimox.<\/jats:p>","DOI":"10.1111\/tid.13429","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T19:40:30Z","timestamp":1596310830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["American trypanosomiasis (Chagas disease) in solid organ transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-6156","authenticated-orcid":false,"given":"Marcelo V.","family":"Radisic","sequence":"first","affiliation":[{"name":"d. Institute. Instituto de Trasplante y Alta Complejidad (ITAC) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-9190","authenticated-orcid":false,"given":"Silvia A.","family":"Repetto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM) Facultad de Medicina Universidad de Buenos Aires Consejo Nacional de Investigaciones Cientificas y Tecnicas Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Chagas Disease (American trypanosomiasis). (https:\/\/www.who.int\/en\/news\u2010room\/fact\u2010sheets\/detail\/chagas\u2010disease\u2010(american\u2010trypanosomiasis)Accessed January 14th 2020)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31612-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9211-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385863-4.00002-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0316"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00065-2"},{"issue":"8","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4067\/S0034-98872004000800005","article-title":"Alteraciones motoras gastrointestinales en la enfermedad de Chagas","volume":"132","author":"Madrid S AM","year":"2004","journal-title":"Revista m\u00e9dica de Chile"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"156","article-title":"Peripheral nervous system involvement in human and experimental chronic American trypanosomiasis","volume":"88","author":"Sica RE","year":"1995","journal-title":"Bull Soc Pathol Exot"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65052-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28797-3_44"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.11.008"},{"issue":"6","key":"e_1_2_8_14_1","first-page":"367","article-title":"Chagasic meningoencephalitis with detection of Trypanosoma cruzi in the cerebrospinal fluid of an immunodepressed patient","volume":"97","author":"Jardim E","year":"1994","journal-title":"J Trop Med Hyg"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.10.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00731.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.09.019"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr313"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13546"},{"key":"e_1_2_8_20_1","unstructured":"Recomendaciones para la evaluaci\u00f3n de donantes de TOS. (Guidelines for Solid Organ Transplant donor screening) Sociedad Argentina de Infectologia.https:\/\/drive.google.com\/file\/d\/1du1SB35iw8dMqtDfSG1kbIhEiE7KrYnS\/view. Accessed May 9th 2020."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139363"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002019"},{"key":"e_1_2_8_23_1","unstructured":"Guias para la atenci\u00f3n del paciente infectado con Trypanosoma cruzi (Guidelines for Care of Patients infected with Trypanosoma cruzi). Ministerio de Salud. Republica Argentina.http:\/\/www.anlis.gov.ar\/inp\/wp\u2010content\/uploads\/2015\/03\/guia\u2010para\u2010la\u2010atencion\u2010al\u2010paciente\u2010con\u2010chagas_baja.pdf. Accessed January 20th 2020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02107.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0735"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.10.1134-a"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.02.019"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.08.020"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30538-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313122"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2015.04.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001689"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.02.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02587-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit199"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00235-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2018.04.003"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.02.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.06.015"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.12.046"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13209"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12507"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01820.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00975.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12996"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000277526.68754.02"},{"key":"e_1_2_8_47_1","volume-title":"UpToDate","author":"Bern C","year":"2020"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03800.x"},{"issue":"10","key":"e_1_2_8_49_1","first-page":"988","article-title":"Chagas\u2019 disease reactivation after heart transplantation: efficacy of allopurinol treatment","volume":"15","author":"Almeida DR","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/598634"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-201211271-01070"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000437673.86339.82"},{"issue":"3","key":"e_1_2_8_53_1","article-title":"Chagas Disease and Outcome in Kidney Transplant","volume":"17","author":"Taylor M","year":"2017","journal-title":"Am J Transplant"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12340"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1527-6465(05)80113-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1527-6465(05)80112-1"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12782"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01663.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04160.x"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0156"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12783"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1086\/598931"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.02.032"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir956"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00313"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:09:30Z","timestamp":1693764570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,16]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/tid.13429"],"URL":"https:\/\/doi.org\/10.1111\/tid.13429","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,16]]},"assertion":[{"value":"2020-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13429"}}