{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:39:39Z","timestamp":1760240379820,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syphilis is capable of compromising almost any organ; however, syphilitic hepatitis is a rare manifestation that has been described most often in HIV\u2010infected patients. Herein, we present a 33\u2010year\u2010old male liver transplant recipient who presented with progressive liver dysfunction characterized by mild ALT elevation and rising cholestasis, malaise, skin rash, and alopecia. Skin biopsy was characteristic of secondary syphilis, confirmed by both skin and liver biopsy\u2010positive immunohistochemical staining for <jats:italic>Treponema pallidum<\/jats:italic>. The patient was treated with benzathine penicillin G 2.4 million units IM q week\u00a0\u00d7\u00a03\u00a0weeks. Three months later, the patient was asymptomatic and recovered from his general malaise. He showed no skin lesions and demonstrated complete regrowth of the hair\u00a0on his scalp, beard, and eyebrows. The presence of liver dysfunction with cholestasis in a transplant recipient should alert transplant providers to the possibility of syphilitic hepatitis, particularly in men who have sex with men. Though not an early manifestation, cutaneous signs of secondary syphilis may be a helpful diagnostic indicator in most cases.<\/jats:p>","DOI":"10.1111\/tid.13431","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T21:30:40Z","timestamp":1596317440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secondary syphilis with liver involvement in a liver transplant recipient"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-9596","authenticated-orcid":false,"given":"Carla","family":"Ferr\u00e1ndiz\u2010Pulido","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Pathology Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Len","sequence":"additional","affiliation":[{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Infectious Diseases Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluis","family":"Castells","sequence":"additional","affiliation":[{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Liver Unit Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12734"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH14174"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2005.04.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000180455.79024.e9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2018.00003"},{"key":"e_1_2_7_7_1","first-page":"94","article-title":"The great imposter, the great imitator","volume":"18","author":"Aman S","year":"2011","journal-title":"Br J Dermatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)43558-0"},{"key":"e_1_2_7_9_1","first-page":"442","article-title":"Secondary syphilis after renal transplantation","volume":"1","author":"Ballout A","year":"2008","journal-title":"NDT Plus"},{"key":"e_1_2_7_10_1","first-page":"524","article-title":"Syphilis\u2010related hepatitis in a liver transplant patient","volume":"5","author":"Camara B","year":"2007","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00531.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.09.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91183-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.1.236"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz317"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199802270-00029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)01185-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00745.x"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:08:33Z","timestamp":1693688913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,16]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/tid.13431"],"URL":"https:\/\/doi.org\/10.1111\/tid.13431","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2020,8,16]]},"assertion":[{"value":"2020-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13431"}}