{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:08:20Z","timestamp":1773979700821,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>BK polyomavirus (BKV) causes two distinct complications after transplantation, hemorrhagic cystitis (BKV\u2010HC) after hematopoietic stem cell transplantation (HSCT), and BKV\u2010associated nephropathy (BKVAN) after kidney transplantation (KT). Although fluoroquinolones show efficacy against BKV proliferation in vitro, the clinical effect remains uncertain; thus, we performed meta\u2010analysis to assess its efficacy in the prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Articles published before March 2020 were searched from PubMed, the Cochrane Library, ISRCTN registry, and ClinicalTrials.gov. Primary outcomes were BKV\u2010HC after HSCT and BKVAN after KT. Secondary outcomes were BK viremia, viruria after KT, and fluoroquinolone\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three trials with 281 patients post\u2010HSCT and 11 trials with 1882 patients post KT were included as for prophylaxis. Fluoroquinolone prophylaxis did not show effects on BKV\u2010HC (OR 0.54, 95% CI 0.13\u20102.25), BKVAN (OR 0.74, 95% CI 0.35\u20101.55), and BK viremia (OR 0.79, 95% CI 0.49\u20101.28), but significantly decreased BK viruria (OR 0.64, 95% CI 0.45\u20100.91). Fluoroquinolone prophylaxis was associated with the higher percentage of fluoroquinolone\u2010resistant infection among identified bacteria (OR 2.38, 95% CI 1.16\u20104.88), but the incidence of fluoroquinolone\u2010resistant infection was similar (OR 1.15, 95% CI 0.71\u20101.86), due to the decrease of infection itself (OR 0.52, 95% CI 0.34\u20100.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis showed that fluoroquinolones did not prevent BKV\u2010HC after HSCT or BKVAN after KT, although the effect against BKV\u2010HC should be further investigated by randomized controlled trials. Fluoroquinolones could reduce the rate of BK viruria to some extent but may not have clinically sufficient effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13433","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T10:37:08Z","timestamp":1596451028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fluoroquinolones for BK viral complication after transplantation: Meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"given":"Yusuke","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine The University of Tokyo Bunkyo City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine The University of Tokyo Bunkyo City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine The University of Tokyo Bunkyo City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-2422","authenticated-orcid":false,"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine The University of Tokyo Bunkyo City Japan"},{"name":"Department of Cell Therapy and Transplantation Medicine The University of Tokyo Hospital Bunkyo City 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