{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:09:36Z","timestamp":1768252176702,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008810","name":"NSW Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1168202"],"award-info":[{"award-number":["GNT1168202"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood\u2010borne viral infections can complicate organ transplantation. Systematic monitoring to distinguish donor\u2010transmitted infections from other new infections post transplant is challenging. Administrative health data can be informative. We aimed to quantify post\u2010transplant viral infections, specifically those transmitted by donors and those reactivating or arising new in recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We linked transplant registries with administrative health data for all solid organ donor\u2010recipient pairs in New South Wales, Australia, 2000\u20102015. All new recipient notifications of hepatitis B (HBV), C (HCV), or human immunodeficiency virus (HIV) after transplant were identified. Proven\/probable donor transmissions within 12\u00a0months of transplant were classified using an international algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2120 organ donors, there were 72 with a viral infection (9\/72 active, 63\/72 past). These 72 donors donated to 173 recipients, of whom 24\/173 already had the same infection as their donor, and 149\/173 did not, so were at risk of donor transmission. Among those at risk, 3\/149 recipients had proven\/probable viral transmissions (1 HCV, 2 HBV); none were unrecognized by donation services. There were no deaths from transmissions. There were no donor transmissions from donors without known blood\u2010borne viruses. An additional 68 recipients had new virus notifications, of whom 2\/68 died, due to HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work confirms the safety of organ donation in an Australian cohort, with no unrecognized viral transmissions and most donors with viral infections not transmitting the virus. This may support targeted increases in donation from donors with viral infections. However, other new virus notifications post transplant were substantial and are preventable. Data linkage can enhance current biovigilance systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13437","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T05:44:52Z","timestamp":1596865492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New blood\u2010borne virus infections among organ transplant recipients: An Australian data\u2010linked cohort study examining donor transmissions and other HIV, hepatitis C and hepatitis B notifications, 2000\u20102015"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-3292","authenticated-orcid":false,"given":"Karen M. J.","family":"Waller","sequence":"first","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-3656","authenticated-orcid":false,"given":"Nicole L.","family":"De La Mata","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-0862","authenticated-orcid":false,"given":"James A.","family":"Hedley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda M.","family":"Rosales","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"},{"name":"Department of Renal Medicine Royal Prince Alfred Hospital Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"New South Wales Organ and Tissue Donation Service Sydney NSW Australia"},{"name":"Department of Intensive Care Medicine Royal Prince Alfred Hospital Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cavazzoni","sequence":"additional","affiliation":[{"name":"New South Wales Organ and Tissue Donation Service Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidiya","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Serology and Virology Division NSW Health Pathology Randwick Prince of Wales Hospital Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Serology and Virology Division NSW Health Pathology Randwick Prince of Wales Hospital Randwick NSW Australia"},{"name":"Schools of SOMS, BABS and Women's and Children's University of NSW Kensington NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate R.","family":"Wyburn","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Faculty of Health and Medicine Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Webster","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine Sydney School of Public Health Centre for Organ Donation Evidence University of Sydney Sydney NSW Australia"},{"name":"Centre for Transplant and Renal Research Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03597.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12094"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000584"},{"issue":"10","key":"e_1_2_11_5_1","first-page":"297","article-title":"HIV transmitted from a living organ donor\u2013New York City, 2009","volume":"60","author":"Centres for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ec29f0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13547"},{"key":"e_1_2_11_8_1","unstructured":"World Health Organisation (WHO) Collaborating Centre on Vigilance and Surveillance for Human Cells Tissues and Organs.Notify Library: The Global Vigilance and Surveillance Database for Medical Products of Human Origin.https:\/\/www.notifylibrary.org\/. Accessed October 30 2019."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.159"},{"key":"e_1_2_11_10_1","volume-title":"2019 Annual Report, Section 4: Organ Donor Profile","author":"Australia and New Zealand Organ Donation Registry (ANZOD)","year":"2019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000852"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2054358118799692"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.580"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.08.008"},{"issue":"5","key":"e_1_2_11_15_1","first-page":"377","article-title":"Clinical analysis of de novo HBV infection after liver transplantation in non\u2010HBV\u2010 related liver disease","volume":"26","author":"Zhang BC","year":"2018","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_11_16_1","unstructured":"Centre for Health Record Linkage (CHeReL).How Record Linkage Works.http:\/\/www.cherel.org.au\/how\u2010record\u2010linkage\u2010works. Accessed December 16 2019."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-020-09810-x"},{"key":"e_1_2_11_18_1","unstructured":"Communicable Diseases Network Australia (CDNA).Human Immunodeficiency Virus (HIV): CNDA National Guidelines for Public Health Units. In: Australian Government Department of Health ed2014."},{"key":"e_1_2_11_19_1","unstructured":"National Notifiable Diseases Surveillance System (NNDSS).Hepatitis C Acute: 2016 Case Definition. In: Centres for Disease Control and Prevenetino (CDC) ed2016."},{"key":"e_1_2_11_20_1","volume-title":"Clinical Guidelines for Organ Transplantation from Deceased Donors","author":"Transplantation Society of Australia and New Zealand","year":"2019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800403"},{"key":"e_1_2_11_22_1","unstructured":"NSW Health Office of the Chief Health Officer.Organ Donation and Transplantation \u2010 Managing Risks of Transmission of HIV HCV and HBV.2013."},{"key":"e_1_2_11_23_1","volume-title":"Solid Organ Transplantation and the Probability Of Transmitting HIV, HBV, or HCV: A Systematic Review to Support an Evidence\u2010Based Guideline","author":"Treadwell JR","year":"2010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01618.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01254.x"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"33","article-title":"Hepatitis B virus infection and organ transplantation","volume":"14","author":"Ayoub WS","year":"2018","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_11_27_1","unstructured":"Australian Immunisation Handbook. Table.Recommended Vaccines for People Before and After a Solid Organ Transplant.2018;https:\/\/immunisationhandbook.health.gov.au\/resources\/handbook\u2010tables\/table\u2010recommended\u2010vaccines\u2010for\u2010people\u2010before\u2010and\u2010after\u2010a\u2010solid\u2010organ. Accessed November 7 2019."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13563"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000938"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i35.8010"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12921"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14381"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.12.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15031"},{"key":"e_1_2_11_36_1","unstructured":"Organ Procurement and Transplantation Network (OPTN).Unexpeted HCV Donor\u2010Derived Transmissions on the Rise. 2019. Accessed November 7 2019."},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00229.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13514"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50315"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15352"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500050301"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002722"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00547.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000030"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1086\/524324"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-013-9376-y"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3721"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03572.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147087"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.17061\/phrp2751745"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:08:48Z","timestamp":1693764528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/tid.13437"],"URL":"https:\/\/doi.org\/10.1111\/tid.13437","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"assertion":[{"value":"2020-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13437"}}