{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:14:51Z","timestamp":1792854891892,"version":"4.5.0"},"reference-count":100,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplant recipients (KTRs) have increased risk for cytomegalovirus (CMV) infection\/disease given the necessity of drug\u2010induced immunosuppression. A comprehensive review of published literature reporting real\u2010world data on prevention strategies utilized and associated CMV burden outcomes is limited. Such data could help inform future clinical practice and identify unmet needs in CMV management. We conducted a systematic review of observational studies published in Medline or EMBASE from January 2008 to November 2018 to identify current real\u2010world CMV management approaches, CMV infection\/disease risk factors, and outcomes associated with CMV infection. Descriptive statistics and pooled quantitative analyses were conducted. From 1608 records screened, 86 citations, including 69\u00a0803 adult KTR, were included. Prophylaxis and preemptive therapy (PET) were predominant approaches among D+\/R\u2010 and R\u00a0+\u00a0CMV serostatus transplants, respectively. Valganciclovir and ganciclovir were frequently utilized across CMV risk strata. Despite prevention approaches, approximately one\u2010fourth of KTR developed CMV infection. Age and D+\/R\u2010 CMV serostatus were consistent risk factors for CMV infection\/disease. CMV infection\/disease was associated with increased mortality and graft loss. CMV was similarly associated with acute rejection (AR) risk, but with high heterogeneity among studies. Limited data were available on CMV and opportunistic infections (OIs) risk. CMV remains a significant issue. New strategies may be needed to optimize CMV management.<\/jats:p>","DOI":"10.1111\/tid.13483","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T19:30:40Z","timestamp":1601839840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Epidemiology, risk factors, and outcomes associated with cytomegalovirus in adult kidney transplant recipients: A systematic literature review of real\u2010world evidence"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-8612","authenticated-orcid":false,"given":"Amit D.","family":"Raval","sequence":"first","affiliation":[{"name":"Merck &amp; Co, Inc Kenilworth NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin D.","family":"Kistler","sequence":"additional","affiliation":[{"name":"Evidera, Inc Waltham MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Tang","sequence":"additional","affiliation":[{"name":"Merck &amp; Co, Inc Kenilworth NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Murata","sequence":"additional","affiliation":[{"name":"Merck &amp; Co, Inc Kenilworth NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Snydman","sequence":"additional","affiliation":[{"name":"Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02824.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13080"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3129"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2599-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12288"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00735.x"},{"key":"e_1_2_8_9_1","unstructured":"Global Observatory on Donation and Transplantation.http:\/\/www.transplant\u2010observatory.org\/. Accessed April 17 2020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.18.0063"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-5-199703010-00006"},{"key":"e_1_2_8_13_1","unstructured":"HigginsJPT GreenS.Cochrane collaboration handbook for systematic reviews of interventions. The Cochrane Collaboration and John Wiley & Sons Ltd.2008."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12405"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.08.098"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13110"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12256"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318200b9f0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802064705"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12848"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193968"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2009.07.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.11.053"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01521.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.029"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03766.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.140"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000189"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0298-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12846"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.07.070"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.02.020"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12586"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12321"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix259"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000570"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0343-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.10.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23539"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.09.023"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01321.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12247"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12609"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2016.08.007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816c7dc7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194789"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.031"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000438197.38413.f2"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002421"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017728296"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.02.040"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13781"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.057"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12780"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.01.027"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181f7c053"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12227"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01073.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883859"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12972"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2016.11.018"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.04.036"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00759.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12226"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000497"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.10.1166"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000102"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.08.017"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12829"},{"issue":"2","key":"e_1_2_8_72_1","first-page":"224","article-title":"Frequency of cytomegalovirus (CMV) in post renal transplant patients: a single center experience","volume":"43","author":"Munib S","year":"2018","journal-title":"Rawal Medical Journal"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12816"},{"issue":"4","key":"e_1_2_8_74_1","first-page":"363","article-title":"HCMV infection in renal transplant recipients: a retrospective cohort study","volume":"36","author":"Puttini C","year":"2013","journal-title":"The new microbiologica"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12494"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12929"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0175-7"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.12.010"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12706"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001825"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040340"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2126"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02242.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12349"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs531"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2010.10.002"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02490.x"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP88FX27"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12408"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12285"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12657"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.02.006"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.08.290"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit064"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13107"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.068841"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12379"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx062"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz215"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12594"},{"issue":"1","key":"e_1_2_8_101_1","first-page":"23","article-title":"Incidence and risk factors for cytomegalovirus in kidney transplant patients in Babol, northern Iran","volume":"8","author":"Babazadeh A","year":"2017","journal-title":"Caspian J Intern Med"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:15:13Z","timestamp":1693545313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/tid.13483"],"URL":"https:\/\/doi.org\/10.1111\/tid.13483","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"assertion":[{"value":"2020-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13483"}}