{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:40:35Z","timestamp":1790361635123,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The contrasting outcomes of lymphocyte manipulation after solid organ transplantation are allograft rejection and infections, commonly with cytomegalovirus (CMV). Peripheral blood absolute lymphocyte count (ALC) may serve as a predictive marker for these outcomes. Using a retrospective review of clinical and laboratory dataset, we aimed to determine whether a range of ALC (termed \u201csafe ALC corridor\u201d) exists where CMV infection and rejection outcomes are minimal in a cohort of 381 kidney transplant recipients. In an extended Cox model using a time\u2010dependent covariate for peripheral blood ALC, a value below the cut\u2010off of 610 cells\/uL was associated with the development of CMV infection both in the overall cohort (Hazard Ratio [HR] 2.25 (95% confidence internal [CI] 1.02\u20104.96; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.043) and the subgroup of high\u2010risk CMV D+\/R\u2010 mismatch patients (HR 2.91 [95% CI 1.09\u20107.77]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.033). In contrast, a time\u2010dependent Cox analysis did not show any significant association between ALC and rejection (per IQR decrease, HR 1.2 [95% CI: 0.76\u20101.9]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.434). Accordingly, a \u201csafe ALC corridor\u201d could not be defined. In conclusion, a low peripheral blood ALC (ie, threshold of 610\u00a0cells\/uL) can be used to stratify the risk of CMV disease after kidney transplantation.<\/jats:p>","DOI":"10.1111\/tid.13489","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T03:45:15Z","timestamp":1602301515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Absolute lymphocyte count as marker of cytomegalovirus and allograft rejection: Is there a \u201cSafe Corridor\u201d after kidney transplantation?"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-5624","authenticated-orcid":false,"given":"Guy","family":"El Helou","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Rochester MN USA"},{"name":"Division of Infectious Disease and Global Medicine University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lahr","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-0227","authenticated-orcid":false,"given":"Raymund","family":"Razonable","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Rochester MN USA"},{"name":"William J von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S180908"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-065X.2003.00088.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1020-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000168432.60022.99"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.059"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12134"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy295"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002396"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy230"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13680"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_11_13_1","volume-title":"COBAS\u00ae AmpliPrep\/COBAS\u00ae TaqMan\u00ae CMV Test [package insert]","year":"2012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002366"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/528718"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21280"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12447"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:13:51Z","timestamp":1693545231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/tid.13489"],"URL":"https:\/\/doi.org\/10.1111\/tid.13489","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13489"}}