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In immunocompromised patients, HAdV can sometimes cause severe infection such as cystitis, gastroenteritis, pneumonia, encephalitis, hepatitis, or disseminated disease, resulting in significant morbidity and also mortality. In particular, severe cases have been reported in patients after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Indeed HAdV has been recognized as a pathogen that requires careful monitoring in allo\u2010HSCT patients. While HAdV hepatitis leading to severe acute liver failure is rare, such liver failure progresses rapidly and is often fatal. Unfortunately, HAdV hepatitis has few characteristic symptoms and physical findings, which makes it difficult to promptly confirm and start treatment. We report here four cases of HAdV hepatitis after allo\u2010HSCT and their autopsy findings.<\/jats:p>","DOI":"10.1111\/tid.13496","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T18:44:51Z","timestamp":1603133091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-4974","authenticated-orcid":false,"given":"Yoshiyuki","family":"Onda","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Takatsuki Red Cross Hospital Osaka Japan"},{"name":"Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto 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