{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:35Z","timestamp":1760123015775,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is a relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo\u2010HSCT) in developing countries. Herein, we describe the incidence rates of different infections according to the transplant period and baseline condition in Colombia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study of all children who underwent allo\u2010HSCTs from 2012 to 2017 in a hospital in Cali, Colombia, we reviewed medical records from the first post\u2010transplant day until day\u00a0+\u00a0365 to describe microbiologically confirmed incidence rates of infections and deaths during three post\u2010transplant periods and according to baseline condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most allo\u2010HSCT (n\u00a0=\u00a0144, 96%) were followed by infections over the following year, mostly due to bacteria and cytomegalovirus (4.3 and 3.3 per 1000 patient\u2010days, respectively). Children were at the highest risk for infection in the first 30\u00a0days post\u2010HSTC, but mortality was highest after 100\u00a0days. Overall, high mortality (n\u00a0=\u00a044, 31.7%) was associated with infections, especially from extensively drug\u2010resistant bacteria, adenovirus, and aspergillosis. Infection rates were similar independent of the baseline condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Almost all children in this cohort developed infections post allo\u2010HSCT. Describing the distribution of infections throughout the first post allo\u2010HSCT year allows clinicians to narrow the differential diagnosis of infections according to the post\u2010transplant period. This is especially useful when prioritizing interventions in children receiving HSCT in stringent healthcare systems in developing countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13498","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T19:18:32Z","timestamp":1603999112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Infectious complications after allogeneic hematopoietic stem cell transplantation in children in a bone marrow transplant unit in Colombia"],"prefix":"10.1111","volume":"23","author":[{"given":"Ana Milena","family":"Bravo","sequence":"first","affiliation":[{"name":"Universidad del Cauca Popay\u00e1n Colombia"},{"name":"Hospital Universitario San Jos\u00e9 Popay\u00e1n Colombia"},{"name":"Cl\u00ednica Nueva Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jailer","family":"Arango","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda Universidad del Valle Cali Colombia"},{"name":"Unidad Maternoinfantil del Tolima Cl\u00ednica Medicadiz Ibagu\u00e9 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Registro Poblacional de C\u00e1ncer de Cali Cali Colombia"},{"name":"Centro M\u00e9dico Imbanaco Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Andres","family":"Portilla","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda Universidad del Valle Cali Colombia"},{"name":"Centro M\u00e9dico Imbanaco Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pio","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda Universidad del Valle Cali Colombia"},{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Calle","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica Cali Colombia"},{"name":"Departamento de Pediatr\u00eda Universidad del Quind\u00edo Armenia Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-5938","authenticated-orcid":false,"given":"Eduardo","family":"L\u00f3pez\u2010Medina","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda Universidad del Valle Cali Colombia"},{"name":"Centro M\u00e9dico Imbanaco Cali Colombia"},{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica Cali 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