{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:47:55Z","timestamp":1792504075321,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the abnormalities of the upper gastrointestinal tract in liver transplant (LT) recipients, especially the prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> infection and the incidence of chronic atrophic gastritis (CAG), and to explore the efficacy and safety of <jats:italic>H pylori<\/jats:italic> eradication treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endoscopic screening was performed prospectively on LT recipients who received regular follow\u2010up in our center. A group of healthy subjects with same age and sex was selected as a control group at a ratio of 1:3 with propensity score matching. All <jats:italic>H pylori<\/jats:italic>\u2010positive recipients received Bismuth\u2010containing quadruple therapy (esomeprazole 20\u00a0mg\u00a0+\u00a0clarithromycin 500\u00a0mg\u00a0+\u00a0amoxicillin 1\u00a0g\u00a0+\u00a0bismuth 220\u00a0mg, all of the medicines were applied twice daily, for 14\u00a0days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The prevalence of <jats:italic>H pylori<\/jats:italic> infection was significantly lower in LT group than control group [12\/102 (11.8%) vs 98\/306 (32.0%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001], whereas the prevalence of CAG was similar between the two groups [48\/102 (47.1%) vs 138\/306 (45.1%), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.731]. Meanwhile, the incidence of reflux esophagitis [18\/102 (17.6%) vs 31\/306 (10.1%), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.043] and bile regurgitation [19\/102 (18.6%) vs 30\/306 (9.8%), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018] were higher in LT group. No correlation between the incidence of upper gastroduodenal abnormalities and postoperative time after liver transplantation was found. The success rate of <jats:italic>H pylori<\/jats:italic> eradication therapy was 100% (10\/10). The blood concentration of immunosuppressants was 1.7\u20103.6 times above baseline values during <jats:italic>H pylori<\/jats:italic> eradication therapy; however, no severe adverse effects were observed during the proceed with dose adjustments of the immunosuppressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the prevalence of <jats:italic>H pylori<\/jats:italic> infection was lower in LT recipients than in control subjects, the prevalence of CAG was like that of the general population. <jats:italic>H pylori<\/jats:italic> eradication therapy was safe and effective after liver transplantation in our preliminary study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13513","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T23:46:58Z","timestamp":1605743218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic atrophic gastritis and 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