{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:49:21Z","timestamp":1761709761159,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Viral infections, principally cytomegalovirus, Epstein Barr virus (EBV) and adenovirus, are a leading cause of morbidity and mortality after allogeneic stem cell transplantation. The use of systemic antivirals is limited by limited efficacy and organ toxicities. Inability to clear infection is exacerbated by transplant\u2010related immunosuppression and prophylaxis or treatment of acute graft versus host disease. We report the first patient to clear three serious viral infections after stem cell transplant using third\u2010party donor partially human leukocyte antigen (HLA) matched virus\u2010specific cytotoxic T cells. The patient, a 53\u00a0year old female with transplanted for relapsed leukemia, with severe graft versus host disease received five T cell infusions from three separate donors that ultimately cleared serious systemic infections with cytomegalovirus and adenovirus, and an EBV\u2010driven lymphoma. Systemic antivirals had resulted in failed clinical responses. Use of repeated infusions of partially HLA matched virus\u2010specific T cells from banks containing cryopreserved cells should be strongly considered in transplant recipients with single or multiple refractory viral infections.<\/jats:p>","DOI":"10.1111\/tid.13528","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T07:50:45Z","timestamp":1606290645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Successful treatment of CMV, EBV, and adenovirus tissue infection following HLA\u2010mismatched allogeneic stem cell transplant using infusion of third\u2010party T cells from multiple donors in addition to antivirals, rituximab, and surgery"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-8619","authenticated-orcid":false,"given":"Pietro R.","family":"Di Ciaccio","sequence":"first","affiliation":[{"name":"Department of Haematology Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selmir","family":"Avdic","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant and Cell Therapies Program Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Sutrave","sequence":"additional","affiliation":[{"name":"Department of Haematology Westmead Hospital Sydney NSW Australia"},{"name":"Stem Cell Transplant and Cell Therapies Program Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leighton","family":"Clancy","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant and Cell Therapies Program Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Withers","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant and Cell Therapies Program Westmead Hospital Sydney 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