{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:36:17Z","timestamp":1753878977532,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008648","name":"Pfizer Foundation","doi-asserted-by":"publisher","award":["PFI\u2010260399\/FP00105263\/17\u2010004563"],"award-info":[{"award-number":["PFI\u2010260399\/FP00105263\/17\u2010004563"]}],"id":[{"id":"10.13039\/100008648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optimizing immunity against vaccine\u2010preventable diseases improves outcomes in kidney transplant (KT) patients (Arora et al,<jats:italic>World J Transplant<\/jats:italic>, 2019, 9:1; Sester et al,<jats:italic>Transplant Rev<\/jats:italic>, 2008, 22:274; Fishman,<jats:italic>N Engl J Med<\/jats:italic>, 2007, 357:2601). The American Society for Transplantation (AST) Clinical Practice Guidelines advises that serologic screening for measles, mumps, and rubella (MMR) be conducted for all KT candidates, since live\u2010attenuated vaccines are contraindicated post\u2010transplantation (Malinis et al,<jats:italic>Clin Transplant<\/jats:italic>, 2019, 33:e13548). Our team at Mayo Clinic Florida (MCF) conducted a quality improvement (QI) initiative to establish a best MMR screening and immunizations clinical practice in KT candidates using a Plan\u2010Do\u2010Study\u2010Act (PDSA) model. By retrospective chart review of all KT candidates evaluated at our institution from January 1, 2016 to December 31, 2017, baseline data determining the rate of MMR serologic screening was established. PDSA cycles were implemented to adopt protocol\u2010driven testing for MMR serologies, immunization documentation, and vaccination in cases of seronegativity to any of the three MMR viruses in all pre\u2010KT candidates. Two PDSA cycles were completed in 4\u00a0months. The study population totaled 447 patients (baseline n\u00a0=\u00a0283, PDSA 1 n\u00a0=\u00a061, PDSA 2 n\u00a0=\u00a0103). Baseline data showed that 83% (n\u00a0=\u00a0235) of pre\u2010KT candidates received infectious disease consultation (IDC). Complete MMR (all three viruses) serological screening in KT candidates improved from baseline 3.9%\u201087.4% post\u2010PDSA cycle 2 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Necessary immunizations per AST guidelines were ordered in only 41.1% (n\u00a0=\u00a023) of the control cohort vs 100% (n\u00a0=\u00a012) and 96.9% (n\u00a0=\u00a031) of PDSA cycles 1 and 2, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The data reflect significant practice improvements in MMR screening and immunization rates among KT candidates by using protocol\u2010driven orders combined with our pre\u2010existing IDCs.<\/jats:p>","DOI":"10.1111\/tid.13529","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T20:15:50Z","timestamp":1606594550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishing best practices in measles, mumps, and rubella serologic screening for kidney transplant candidates"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-8292","authenticated-orcid":false,"given":"Jahanavi M.","family":"Ramakrishna","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Brumble","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly L.","family":"Larimore","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-0897","authenticated-orcid":false,"given":"Hani M.","family":"Wadei","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tambi","family":"Jarmi","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-6802","authenticated-orcid":false,"given":"Claudia R.","family":"Libertin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v9.i1.1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2008.07.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13548"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12473"},{"volume-title":"2020 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1988\u20132020","year":"2020","author":"Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD","key":"e_1_2_10_7_1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.06.058"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"e13202","DOI":"10.1111\/tid.13202","article-title":"Serologic screening and infectious disease consultation (IDC): indicated in heart, lung, liver (HLL) solid organ transplants (SOT) for measles, mumps, rubella, and varicella","volume":"22","author":"Seckin ZI","year":"2019","journal-title":"Transpl Infect Dis"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04410512"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121113"},{"volume-title":"The Improvement Guide: A Practical Approach to Enhancing Organizational Performance","year":"2009","author":"Langley 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