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However, the incidence of HHV\u20106 reactivation and the clinical outcomes following unmanipulated haploidentical HSCT (haplo\u2010HSCT) remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We prospectively monitored blood HHV\u20106 DNA using real\u2010time quantitative polymerase chain reaction weekly until day 100 post unmanipulated haplo\u2010HSCT in patients with hematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From November 2016 to March 2017, 102 patients (58 male and 44 female, median age 25(2\u201058) years old) were enrolled. Within 100\u00a0days post\u2010transplantation, 27 patients (27\/136, 19.9%) developed HHV\u20106 viremia with a median onset time of 14 (7\u201098) days. The cumulative incidence of HHV\u20106 reactivation on day 100 post\u2010HSCT was 25.5\u00a0\u00b1\u00a04.3% in haplo\u2010HSCT. The median HHV\u20106 copy number was 1.45\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup> (5.48\u00a0\u00d7\u00a010<jats:sup>2<\/jats:sup>\u20102.00\u00a0\u00d7\u00a010<jats:sup>4<\/jats:sup>) copies\/ml. The HHV\u20106 viremia duration time was 7\u00a0days in 23 patients, 14\u00a0days in one patient and 21\u00a0days in one patient. In multivariate analysis, prior HHV\u20106 reactivation was an independent risk factor for grade 2\u20104 graft\u2010versus\u2010host disease (GVHD). But it did not influence the overall survival (OS)(HR 1.624, 95%CI 0.768\u20103.432, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.204), disease\u2010free survival (DFS) (HR 1.640, 95%CI 0.799\u20103.367, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.177) and non\u2010relapse mortality (NRM) (HR 1.644, 95%CI 0.670\u20104.038, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.278).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reactivation of HHV\u20106 after unmanipulated haploidentical transplantation predicts the occurrence of grade 2\u20104 a\u2010GVHD, but it may not influence the overall survival (OS), disease\u2010free survival (DFS) and non\u2010relapse mortality (NRM).<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13544","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T20:18:41Z","timestamp":1608236321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human herpesvirus 6 reactivation in unmanipulated haploidentical hematopoietic stem cell transplantation predicts the occurrence of grade II to IV acute graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Ting\u2010Ting","family":"Han","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 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Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Fei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 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