{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:52:59Z","timestamp":1770634379429,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heart transplant (HT) remains the most frequently indicated therapy for patients with end\u2010stage heart failure that improves prognosis in Chagas cardiomyopathy (CCM). However, the lack of benznidazole therapy and availability of RT\u2010PCR follow\u2010up in many centers is a major limitation to perform this life\u2010saving intervention, as there are concerns related with the risk of reactivation. We aimed to describe the outcomes of a cohort of patients with CCM who underwent HT using a conventional protocol with mycophenolate mofetil, without benznidazole prophylaxis or RT\u2010PCR follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study. Between 2008 and 2018, 43 patients with CCM underwent HT. A descriptive analysis to characterize outcomes as rejection, infectious and neoplastic complications and a survival analysis was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median of follow\u2010up was 4.3 (IR 4.28) years. Survival at 1\u00a0month, 1\u00a0year, and 5\u00a0years was 95%, 85%, and 75%, respectively, infections being the main cause of death (60%). Reactivations occurred in only three patients (7.34%) and were not related to mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This cohort showed a favorable survival and a low reactivation rate without an impact on mortality. Our results suggest that performing HT in patients with CCM following conventional guidelines and recommendations for other etiologies is a safe approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13549","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T20:36:41Z","timestamp":1608583001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Survival after heart transplantation for Chagas cardiomyopathy using a conventional protocol: A 10\u2010year experience in a single center"],"prefix":"10.1111","volume":"23","author":[{"given":"Luis E.","family":"Echeverr\u00eda","sequence":"first","affiliation":[{"name":"Heart Failure and Heart Transplant Clinic Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"},{"name":"Advanced Heart Failure Group Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Group Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"},{"name":"Cardiovascular Surgery Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Clinic Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Salazar","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Group Fundaci\u00f3n Cardiovascular de Colombia Floridablanca Colombia"},{"name":"Extracorporeal Membrane Oxygenation (ECMO) and Mechanical Support Program Fundaci\u00f3n Cardiovascular de Colombia Floridablanca 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