{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:28:50Z","timestamp":1792758530934,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of chronic immunosuppression on the course of chikungunya virus (CHIKV) infection in recipients of solid organ transplantation (SOT) is still unsettled. Scarce data suggest that the course of CHIKV infection is generally benign in this population. In addition, the occurrence of severe atypical manifestations associated with CHIKV has not been well documented among SOT recipients. In this report, we describe a 64\u2010year\u2010old male liver transplant recipient who was admitted with fever, headache, arthralgia, left palpebral ptosis, mydriasis, and right hemiparesis. Cranial magnetic resonance imaging did not reveal any alteration suggestive of acute infection. Nevertheless, CHIKV was detected in the cerebrospinal fluid (CSF) with a real\u2010time reverse transcriptase assay. Other PCR assays carried out in CSF were negative for HSV\u20101 and 2, cytomegalovirus, dengue virus (DENV), and Zika virus (ZIKV). CHIKV viremia was also detected while PCR assays for ZIKV and DENV in the blood were negative. ZIKV viruria was simultaneously present in this case. All neurologic manifestations waned within 2\u00a0weeks after the onset. This report shows that chikungunya must be considered in the differential diagnosis of acute neurologic disease in SOT recipients who live in or have recently traveled to endemic areas.<\/jats:p>","DOI":"10.1111\/tid.13554","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T21:39:07Z","timestamp":1609191547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuroinvasive chikungunya in a liver transplant recipient"],"prefix":"10.1111","volume":"23","author":[{"given":"Eduardo Scarlatelli","family":"Pimenta","sequence":"first","affiliation":[{"name":"Departamento de Doen\u00e7as Infecciosas e Parasit\u00e1rias Faculdade de Medicina Federal University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas e Parasit\u00e1rias Hospital Universit\u00e1rio Clementino Fraga Filho Federal University of Rio de Janeiro Rio de Janeiro 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