{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:45:11Z","timestamp":1753879511338,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Invasive candidiasis is one of the common infections in solid organ transplant recipients. Guidelines recommend echinocandins or liposomal amphotericin with consideration of flucytosine (5\u2010fluorocytosine; 5\u2010FC) as synergistic therapy for treatment of select deep\u2010seated Candida infections, including complex endovascular infections. Flucytosine undergoes extensive renal elimination; however, optimal dosing in patients with renal impairment, or those requiring renal replacement therapy (RRT), is not well\u2010established. We describe a case of a 60\u2010year old female who underwent orthotopic heart transplant complicated by <jats:italic>Candida parapsilosis complex<\/jats:italic> fungemia with mediastinitis and development of end\u2010stage renal disease requiring RRT. Flucytosine therapeutic drug monitoring was performed on continuous veno\u2010venous hemofiltration (CVVH) and intermittent hemodialysis (iHD) to guide appropriate dosing. Our results support 5\u2010FC doses of 25\u00a0mg\/kg daily while undergoing CVVH with a low fluid replacement rate and 21\u00a0mg\/kg post\u2010iHD or 17\u00a0mg\/kg daily while receiving thrice weekly iHD.<\/jats:p>","DOI":"10.1111\/tid.13575","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T21:28:18Z","timestamp":1612387698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic drug monitoring of flucytosine in a cardiac transplant patient receiving continuous veno\u2010venous hemofiltration and intermittent hemodialysis: A case report"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-9192","authenticated-orcid":false,"given":"Kelsey N.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Pharmacy Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique R.","family":"Bidell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-0383","authenticated-orcid":false,"given":"Meagan L.","family":"Adamsick","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramy H.","family":"Elshaboury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille N.","family":"Kotton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronak G.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13623"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.28"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444397949"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.171"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm389"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-5-613"},{"volume-title":"Ancobon (5\u2010FC) Package 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