{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:45:11Z","timestamp":1753879511545,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Cryptococcus neoformans<\/jats:italic> is rarely associated with peritonitis in cirrhotic patients; nevertheless, it has a high mortality rate. Early diagnosis and prompt treatment may be the determining prognostic factors. This is a report of two patients awaiting a liver transplant who had opposite outcomes after the diagnosis of spontaneous cryptococcal peritonitis. In Patient 1, the fungal culture was positive in the blood and ascites. She had a poor evolution and died, which was likely caused by the delayed diagnosis and concomitant bacterial infections. In Patient 2, the fungus was found in the ascites, urine, and cerebrospinal fluid cultures. Antifungal treatment was effective. He underwent a liver transplant on the 83rd day of antifungal therapy and is still alive 1\u00a0year later. It is important to suspect fungal etiology when there is a lack of response to antibiotics in patients with decompensated cirrhosis and spontaneous peritonitis, and physicians must be aware of leukocyte count in the ascitic fluid, which is not so high in these cases. This report also emphasizes the need for the routine use of blood culture bottles for microbiological analysis of the ascitic fluid, as it was helpful to diagnose fungal peritonitis in both cases.<\/jats:p>","DOI":"10.1111\/tid.13583","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T16:30:12Z","timestamp":1613320212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cryptococcal peritonitis in patients on the liver transplant waitlist: Reporting two cases with opposite outcomes"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-1377","authenticated-orcid":false,"given":"Ana Caroline","family":"Ferreira da Silva","sequence":"first","affiliation":[{"name":"Division of Gastroenterology (Gastrocentro) University of Campinas (Unicamp) Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlone","family":"Cunha\u2010Silva","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Gastrocentro) University of Campinas (Unicamp) Campinas Brazil"},{"name":"Unit of Liver Transplantation Hospital de Clinicas University of Campinas (Unicamp) Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ferraz Mazo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Gastrocentro) University of Campinas (Unicamp) Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauy Frujuello","family":"Mana","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Gastrocentro) University of Campinas (Unicamp) Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosival","family":"Vicente de Paula","sequence":"additional","affiliation":[{"name":"Division of 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