{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:14Z","timestamp":1753879574008,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01120"],"award-info":[{"award-number":["PI17\/01120"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immunomodulatory effects attributable to cytomegalovirus (CMV) would predispose to BK polyomavirus (BKPyV) infection after kidney transplantation (KT), although available evidence is conflicting. It has been suggested that (val)ganciclovir therapy may increase the risk of BKPyV viremia and BKPyV\u2010associated nephropathy (BKPyVAN) as a result of drug\u2010induced T\u2010cell impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated whether CMV replication and\/or (val)ganciclovir exposure (either as prophylaxis or treatment) were associated with the development of BKPyV viremia or BKPyVAN in a prospective cohort of 399 KT recipients. CMV infection (any level or high\u2010level viremia and area under the curve of DNAemia) and (val)ganciclovir exposure (any duration of therapy and cumulative days of treatment) during the first post\u2010transplant year were explored through separate landmark survival analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative incidence of BKPyV viremia and BKPyVAN after a median follow\u2010up of 551\u00a0days was 23.1% and 2.5%, respectively. One\u2010year rates of CMV infection and (val)ganciclovir therapy were 47.4% and 54.1%, respectively. No differences were observed in BKPyV viremia\u2010 or BKPyVAN\u2010free survival according to previous CMV infection or (val)ganciclovir exposure in any of the landmark analyses. Adjusted Cox models confirmed this lack of association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings do not confirm the existence of a relevant impact of CMV infection or (val)ganciclovir therapy on the risk of post\u2010transplant BKPyV events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13597","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T06:25:24Z","timestamp":1615357524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2150-5748","authenticated-orcid":false,"given":"Isabel","family":"Rodr\u00edguez\u2010Goncer","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12) Madrid Spain"},{"name":"Department of Medicine School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-3043","authenticated-orcid":false,"given":"Mar\u00eda","family":"Ruiz\u2010Ruig\u00f3mez","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7529","authenticated-orcid":false,"given":"Francisco","family":"L\u00f3pez\u2010Medrano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12) Madrid Spain"},{"name":"Department of Medicine School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Corbella","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Polanco","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Gonz\u00e1lez Monte","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital 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