{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:20:38Z","timestamp":1790544038615,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reactivation of BK virus (BKV) can occur during intensive immunosuppression such as in allogenic hematopoietic stem cell transplant (AHSCT) recipients for whom a systematic PCR urine test for BKV will be positive in 50% to 100% of patients. Only 5% to 40% will develop BKV hemorrhagic cystitis (HC). Thus, BKV PCR testing is useful to confirm a diagnosis of BKV\u2010HC but not to predict its occurrence. The aim of this retrospective study was to ascertain the risk factors of developing BKV HC, mostly in patients receiving posttransplant cyclophosphamide. The study looked at data from Grenoble Alpes University Hospital included in the national retrospective register ProMISe, administered by the \u201cSoci\u00e9t\u00e9 Francophone de Greffe de Moelle et de Th\u00e9rapie Cellulaire\u201d. Urine BKV PCR was performed when patients presented grade\u00a0\u2265\u00a02 hematuria with clinical symptoms of cystitis. BKV\u2010HC was defined as an association of clinical symptoms of cystitis, grade\u00a0\u2265\u00a02 hematuria and BKV viruria\u00a0&gt;\u00a07 log<jats:sub>10<\/jats:sub> copies\/ml. From January 2014 to January 2018, 168 AHSCTs were considered for analysis, of which 43 (25.6%) developed BKV\u2010HC and 44.9% of the subgroup that received posttransplant cyclophosphamide. After logistic regression, the risk factors associated with BKV\u2010HC were reduced to posttransplantation exposure to cyclophosphamide (OR 4.25, [1.66; 10.87], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), age\u00a0&lt;\u00a040\u00a0y (OR 3.85 [1.51; 9.80], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and corticosteroid therapy (OR 3.86, [1.59; 9.36], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003). Exposure to cyclophosphamide, younger age (&lt;40) and corticosteroid therapy are potential risk factors for BKV\u2010HC.<\/jats:p>","DOI":"10.1111\/tid.13601","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T12:21:55Z","timestamp":1615897315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk factors of BK viral hemorrhagic cystitis in allogenic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-6493","authenticated-orcid":false,"given":"El\u00e9onore","family":"Kaphan","sequence":"first","affiliation":[{"name":"Department of Hematology Bone Marrow Transplant Unit CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaele","family":"Germi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Bailly","sequence":"additional","affiliation":[{"name":"Institut de Biologie Structurale UMR5075 CEA\u2010CNRS\u2010UGA Grenoble France"},{"name":"University of Grenoble Alpes Inserm CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude\u2010Eric","family":"Bulabois","sequence":"additional","affiliation":[{"name":"Department of Hematology Bone Marrow Transplant Unit CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology Bone Marrow Transplant Unit CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Cahn","sequence":"additional","affiliation":[{"name":"Department of Hematology Bone Marrow Transplant Unit CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Thiebaut\u2010Bertrand","sequence":"additional","affiliation":[{"name":"Department of Hematology Bone Marrow Transplant Unit CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/321813"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"172","article-title":"BK virus infection in transplant recipients: clinical manifestations, treatment options and the immune response","volume":"70","author":"Aalderen MC","year":"2012","journal-title":"Neth J 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