{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:40:30Z","timestamp":1763037630875,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Female renal transplant recipients (RTR) are at high risk of human papillomavirus (HPV)\u2010related anogenital premalignancies and cancer. The aim of this study was to estimate the incidence of cervical intraepithelial lesions (IL) and HPV infection, and their associated factors, in Mexican RTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective cohort study conducted between January 2011 and December 2017. Demographic, clinical, and gynecological data were collected using a previously designed questionnaire. Gynecological examination, cervical cytology, and detection of high\u2010 and low\u2010risk HPV DNA were undertaken prior to and after the renal transplant (RT). Colposcopically guided biopsies were obtained from patients who presented high grade squamous intraepithelial lesions (HSIL) during the follow\u2010up period. Diagnoses were established according to the Bethesda system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 130 RTR, 62 were eligible for our study. The overall incidence of IL was 17.7% (95% CI, 8% to 27%), (11\/62 patients), at 25.6\u00a0\u00b1\u00a010.7\u00a0months post\u2010RT. Nine out of the eleven affected patients had low\u2010grade squamous intraepithelial lesions (81.8%) and only two had HSIL (18.2%). The incidence of HPV infection, determined in a subgroup of 30 RTR, was 53.3% (95% CI, 35% to 71%), (16 out of 30 patients), at 18.3\u00a0\u00b1\u00a08.9\u00a0months post\u2010RT. High\u2010risk HPV genotypes were present in 62.5% of HPV positive cases (10\/16). In 11 patients (36.6%), HPV infection was not associated to IL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPV infection and cervical IL are common in the early posttransplant period. Our findings support the need of screening for cervical cancer to detect precancerous changes in RTR and the need of strengthening the knowledge of medical personnel on this issue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13622","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T14:47:45Z","timestamp":1619016465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence of cervical intraepithelial lesions and human papilloma virus infection in female renal transplant recipients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4053","authenticated-orcid":false,"given":"Idalia","family":"Parra\u2010Avila","sequence":"first","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Jim\u00e9nez\u2010Santana","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Elena","family":"Barr\u00f3n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Areli","family":"Mart\u00ednez\u2010Gamboa","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-1353","authenticated-orcid":false,"given":"Josefina","family":"Alber\u00fa","sequence":"additional","affiliation":[{"name":"Department of Transplants Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"},{"name":"Tecnol\u00f3gico de Monterrey Escuela de Medicina y Ciencias de la Salud Campus CDMX Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-484X","authenticated-orcid":false,"given":"Luis Eduardo","family":"Morales\u2010Buenrostro","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-4716","authenticated-orcid":false,"given":"Ma.\u2010del\u2010Carmen","family":"Cravioto","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-005-0023-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.128"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.28922"},{"volume-title":"Cancer Facts & Figures 2017","year":"2017","author":"American Cancer Society","key":"e_1_2_9_5_1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2823"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2050"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00177-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.6.394"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2436"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380703"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"251","article-title":"Human papillomavirus and lower genital neoplasia in renal transplant patients","volume":"68","author":"Halpert R","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6667.153"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810313"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711063371903"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.5.1108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<611::AID-CNCR2820580303>3.0.CO;2-M"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.074"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13053"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.03.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010201)91:3<412::AID-IJC1071>3.0.CO;2-M"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_9_23_1","unstructured":"Protocolo de Trasplante renal del INCMNSZ versi\u00f3n 2015.http:\/\/www.innsz.mx\/imagenes\/ProtocoloTR\u2010INNSZ\u20102015\u2010ver\u201010.pdf. Accessed February 28 2021."},{"key":"e_1_2_9_24_1","unstructured":"Norma Oficial Mexicana NOM\u2010014\u2010SSA\u20101994 Para la prevenci\u00f3n detecci\u00f3n diagn\u00f3stico tratamiento control y vigilancia epidemiol\u00f3gica del c\u00e1ncer c\u00e9rvico\u2010uterino. Modificaci\u00f3n a la Norma oficial jueves 31 de mayo de 2007.http:\/\/www.salud.gob.mx\/unidades\/cdi\/nom\/m014ssa294.pdf. Accesed February 28 2021."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.6.342"},{"key":"e_1_2_9_26_1","first-page":"313","volume-title":"The Bethesda System for Reporting Cervical Cytology: definitions, Criteria, and Explanatory Notes","author":"Solomon D","year":"2015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb09027.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12714"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji187"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2016.05.016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-019-01261-w"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12329"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:18:56Z","timestamp":1693221536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/tid.13622"],"URL":"https:\/\/doi.org\/10.1111\/tid.13622","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"2020-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13622"}}