{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:44:58Z","timestamp":1791830698750,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The role of pre\u2010HCT chest high\u2010resolution computed tomography (HRCT) and serum galactomannan index (GMI) in predicting the post\u2010allogeneic hematopoietic cell transplant (HCT) invasive pulmonary aspergillosis (IPA) is debatable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, prospective study from 2014 to 2019. The primary objective was to study if pre\u2010HCT chest HRCT and serum GMI predicted IPA post\u2010HCT. The secondary objective was day +100 mortality. All consecutive, consenting patients of \u226512\u00a0years of age undergoing allo\u2010HCT were included and had pre\u2010HCT chest HRCT and serum GMI. All patients received mold active antifungal prophylaxis. The EORTC\/MSG criteria were used for the diagnosis of IPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 82 patients with median age 27\u00a0years (12\u201059\u00a0years) were included. The underlying diagnoses included hematological malignancies (79%) and aplastic anemia (21%). Fifteen percent of patients was treated for prior history of probable IPA (&gt;6\u00a0weeks before HCT). Pre\u2010HCT chest HRCT satisfied EORTC clinical criteria in 24% patients. Serum GMI \u22650.5 was seen in 27% of patients. Post\u2010HCT probable IPA was seen in 24% of patients. There were more patients with pre\u2010HCT chest HRCT findings satisfying EORTC clinical criteria (45% vs. 18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014) and GMI \u22650.5 (45% vs. 21%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) in the group with post\u2010HCT IPA compared to those without IPA. There was higher day+100 mortality in patients with post\u2010HCT IPA (55% vs. 18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of EORTC clinical criteria on pre\u2010HCT chest HRCT, serum GMI \u22650.5, and prior history of IPA predicted post\u2010HCT IPA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13632","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T02:05:31Z","timestamp":1620698731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of pre\u2010transplant chest high\u2010resolution computed tomography and serum galactomannan index in predicting post\u2010transplant invasive pulmonary aspergillosis in allogeneic hematopoietic cell transplant recipients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-1355","authenticated-orcid":false,"given":"Rintu","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8189-8128","authenticated-orcid":false,"given":"Charanpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Khadwal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Postgraduate Institute of Medical Education and Research Chandigarh 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