{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:12:15Z","timestamp":1768803135320,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neutropenia is a serious complication following heart transplantation (OHT); however, risk factors for its development and its association with outcomes is not well described. We sought to study the prevalence of neutropenia, risk factors associated with its development, and its impact on infection, rejection, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010center analysis of adult OHT recipients from July 2004 to December 2017 was performed. Demographic, laboratory, medication, infection, rejection, and survival data were collected for 1\u00a0year post\u2010OHT. Baseline laboratory measurements were collected within the 24\u00a0hours before OHT. Neutropenia was defined as absolute neutrophil count \u22641000 cells\/mm3. Cox proportional hazards models explored associations with time to first neutropenia. Associations between neutropenia, analyzed as a time\u2010dependent covariate, with secondary outcomes of time to infection, rejection, or death were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 278 OHT recipients, 84 (30%) developed neutropenia at a median of 142\u00a0days (range 81\u2010228) after transplant. Factors independently associated with increased risk of neutropenia included lower baseline WBC (HR 1.12; 95% CI 1.11\u20101.24), pre\u2010OHT ventricular assist device (1.63; 1.00\u20102.66), high\u2010risk CMV serostatus [donor positive, recipient negative] (1.86; 1.19\u20102.88), and having a previous CMV infection (4.07; 3.92\u201013.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neutropenia is a fairly common occurrence after adult OHT. CMV infection was associated with subsequent neutropenia, however, no statistically significant differences in outcomes were found between neutropenic and non\u2010neutropenic patients in this small study. It remains to be determined in future studies if medication changes in response to neutropenia would impact patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13634","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T09:34:52Z","timestamp":1620898492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Factors associated with neutropenia post heart transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-7979","authenticated-orcid":false,"given":"Jennifer K. L.","family":"Chow","sequence":"first","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases Tufts Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Ruthazer","sequence":"additional","affiliation":[{"name":"Tufts Clinical and Translational Science Institute Biostatistics, Epidemiology, and Research Design Center Tufts Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen W.","family":"Boucher","sequence":"additional","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases Tufts Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda R.","family":"Vest","sequence":"additional","affiliation":[{"name":"Division of Cardiology Tufts University School of Medicine Tufts Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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