{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:49:46Z","timestamp":1777798186730,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid organ transplant (SOT) recipients are at increased risk of vaccine\u2010preventable illness due to the high degree of immunosuppression required following transplantation. The current recommendation is to vaccinate with live attenuated vaccines, including Measles, Mumps, and Rubella (MMR) and Varicella (VAR) vaccines, at least 4\u00a0weeks prior to transplant. However, data to support the time interval between vaccine and transplant are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conduct a literature review of the natural history of the viruses and length of viremia following live\u2010attenuated viral vaccines, and we describe a series of 5 cases from 2 pediatric transplant centers in which live attenuated viral vaccines were administered within 21\u00a0days prior to SOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 5 children who received MMR or VAR 8\u201021\u00a0days prior to liver (2) and heart (3) transplant suffered from vaccine\u2010related viral illness after transplant, even in the presence of significant immunosuppression with T\u2010cell\u2010depleting agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These cases support that shorter intervals of live vaccine administration prior to transplant may be safe, allowing the vaccination of a larger cohort of SOT candidates. Increasing pretransplant vaccinations is crucial since, in most cases, live viral vaccines are contraindicated posttransplantation, and the most effective vaccine approaches utilize prime\u2010boost strategies, priming before and boosting after transplant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13667","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T08:29:56Z","timestamp":1624004996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Live virus vaccination of pediatric solid organ transplant candidates within 1\u00a0month prior to transplantation: A multicenter experience"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-829X","authenticated-orcid":false,"given":"Ayelet","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-3665","authenticated-orcid":false,"given":"Theresa","family":"Madigan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-258X","authenticated-orcid":false,"given":"Sharon F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-263X","authenticated-orcid":false,"given":"Hayley","family":"Gans","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Stanford 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