{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:27:04Z","timestamp":1773160024891,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of active tuberculosis (TB) in solid organ transplantation (SOT) recipients is challenging given the pharmacological interaction and the potential delays in diagnosis due to atypical presentation. The incidence rates (IRs) of post\u2010SOT TB from the whole recipients\u2019 cohort in a high\u2010endemic country have not been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We established a SOT cohort (<jats:italic>n<\/jats:italic> = 15 598) and confirmed cases of TB between 2011 and 2015 from the Korean National Health Insurance Database using ICD\u201010 codes. After excluding 1302 and 180 SOT\u2010recipients due to age (&lt;18 years) and presence of pre\u2010SOT TB and\/or treatment for latent TB during wash\u2010out period between 2006 and cohort entry, we analyzed 14 116 SOT recipients and 70 580 individuals with no history of SOT matched by age and sex. The hazard ratios (HRs) of IRs were adjusted for age, sex, low\u2010income status, diabetes mellitus, chronic co\u2010morbidities, and anti\u2010TNF\u2010\u03b1 therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IR of TB was significantly higher (adjusted HR [aHR]: 6.1, 95% confidence interval [CI]: 4.5\u20137.6) in SOT recipients (4.9\/1000 person\u2010years) than in non\u2010SOT individuals (0.8\/1000 person\u2010years). Of the transplanted organs, the pancreas (pancreas alone and simultaneous pancreas\u2010kidney) and lung had the highest IR (aHR: 16.3 [6.1\u201342.2] and 16.1 [5.9\u201343.8], respectively). The use of anti\u2010thymocyte globulin and azathioprine was associated with a higher IR (aHR: 1.53 [1.01\u20132.43] and 3.92 [1.21\u201312.47], respectively), but basiliximab was associated with a lower IR (aHR: 0.67 [0.48\u20130.98]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The IR of TB in SOT recipients, especially in the pancreas and lung, was significantly higher than that in the non\u2010SOT population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13729","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T09:54:55Z","timestamp":1631267695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence rate of active tuberculosis in solid organ transplant recipients: Data from a nationwide population cohort in a high\u2010endemic 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