{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:13:31Z","timestamp":1767838411778,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16248"],"award-info":[{"award-number":["21K16248"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BK polyomavirus (BKV) can cause hemorrhagic cystitis (HC) in immunocompromised patients after hematopoietic stem cell transplantation (HSCT). It remains unclear whether nosocomial BKV infections occur. During a 9\u2010month period, an increase in BKV\u2010associated HC (BKV\u2010HC) cases was observed at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The BKV\u2010HC cluster population was compared with populations of HSCT patients from before and after the BKV\u2010HC cluster to evaluate whether nosocomial BKV transmission had occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was carried out to assess the risk of patients developing BKV\u2010HC after HSCT. The background data of the cluster patients were compared with those of the patients who underwent HSCT before or after the cluster, and the collected BKV isolates were serotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BKV\u2010HC involving grade \u22652 hematuria occurred in six of 15 HSCT recipients during a 9\u2010month period. The incidence of BKV\u2010HC was significantly higher in this period than in the other periods (<jats:italic>p<\/jats:italic> = 0.0014). There were no significant differences in the patients\u2019 background data between the cluster and non\u2010cluster periods, including in terms of risk factors for BKV\u2010HC. Serotype analyses of BKV revealed that the BKV detected in the urine samples from four of the six BKV\u2010HC patients belonged to subtype Ic. The gene sequences of these four BKV exhibited &gt;99.5% homology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that nosocomial BKV infections may occur after HSCT. Although many cases of BKV\u2010HC are caused by the reactivation of a latent virus, it is necessary to employ appropriate hygiene measures when cases of BKV\u2010HC occur.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13736","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T15:02:04Z","timestamp":1632236524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A cluster of BK polyomavirus\u2010associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-7476","authenticated-orcid":false,"given":"Hiroki","family":"Hosoi","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama 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