{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:43Z","timestamp":1787065183303,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rational<\/jats:title>\n                    <jats:p>Pending the authorization of new anti\u2010CMV drugs with fewer adverse effects, exploring the possibilities offered by CMV immunoglobulins (CMVIG) seems necessary. In France, access to CMVIG requires official authorization by the national Health authority and is restricted to second line rescue therapy for CMV infection\/disease. The aim of this multicenter retrospective study is to describe the indications and clinical situations that justified its use in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective study included 22 lung transplant patients over a 3\u2010year period. Data on clinical indication, tolerance and efficacy were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main indication for CMVIG initiation, which was documented in 17 of them (82%) was complex clinical situations resulting from side effects to antiviral drug. CMVIG indication was documented as treatment for 15 patients (68%) and as a secondary prophylaxis for 7 patients (32%). Only one side effect (pruritus during infusion with no anaphylactic symptoms) attributable to CMVIG was reported. After CMVIG initiation, no recurrence of infection or disease was observed during a median follow\u2010up of 174 (12\u2013682) days after treatment initiation for respectively 68% and 66% of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study describes an unusual indication of CMVIG use as a last resort treatment in complex situations, based on clinical needs. CMVIG could be useful to change the course of CMV infection with minimal adverse effects or comorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.13754","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T07:14:07Z","timestamp":1635750847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Use of anti\u2010CMV immunoglobulins in lung transplant recipients: The French experience"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-7180","authenticated-orcid":false,"given":"Charlotte","family":"Roy","sequence":"first","affiliation":[{"name":"Pulmonology Department Adult Cystic Fibrosis Centre and Lung Transplantation Department Foch Hospital  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Parquin","sequence":"additional","affiliation":[{"name":"Thoracic Intensive Care Unit Foch Hospital  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-3527","authenticated-orcid":false,"given":"Jonathan","family":"Messika","sequence":"additional","affiliation":[{"name":"Pulmonology Department and Lung Transplant Centre Bichat Hospital Assistance Publique\u2010H\u00f4pitaux de Paris  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boussaud","family":"V\u00e9ronique","sequence":"additional","affiliation":[{"name":"Pulmonology Department Cochin Hospital Assistance Publique\u2010H\u00f4pitaux de Paris  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Brugi\u00e8re","sequence":"additional","affiliation":[{"name":"Pulmonology Department Adult Cystic Fibrosis Centre and Lung Transplantation Department Foch Hospital  Suresnes 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Thorax Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dromer","sequence":"additional","affiliation":[{"name":"Pulmonology Department Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esp\u00e9rie","family":"Burnet","sequence":"additional","affiliation":[{"name":"Pulmonology Department Cochin Hospital Assistance Publique\u2010H\u00f4pitaux de Paris  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Camps","sequence":"additional","affiliation":[{"name":"Pharmacy Department Foch Hospital  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Roux","sequence":"additional","affiliation":[{"name":"Pulmonology Department Adult Cystic Fibrosis Centre and Lung Transplantation Department Foch Hospital  Suresnes 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