{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:37Z","timestamp":1753879597463,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM18\/00221","CP18\/00073","JR18\/00053","PI15\/01953"],"award-info":[{"award-number":["CM18\/00221","CP18\/00073","JR18\/00053","PI15\/01953"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing evidence suggests that infection with the nonpathogenic human pegivirus type 1 (HPgV\u20101) exerts a clinical benefit in human immunodeficiency virus (HIV) patients, which could be attributable to immunomodulatory effects. Whether this impact can be extrapolated to kidney transplantation (KT) remains largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured plasma HPgV\u20101 RNA by real\u2010time polymerase chain reaction targeting the 5\u2032 untranslated region at various points (pretransplantation, day 7, months 1, 3, 6, and 12) in 199 KT recipients. Study outcomes included posttransplant serious infection, immunosuppression\u2010related adverse event (opportunistic infection and\/or de novo cancer), and acute graft rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPgV\u20101 infection was demonstrated in 52 (26.1%) patients, with rates increasing from 14.7% at baseline to 19.1% by month 12 (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.071). De novo infection occurred in 13.8% of patients with no detectable HPgV\u20101 RNA before transplantation. Double\u2010organ (liver\u2013kidney or kidney\u2013pancreas) transplantation (odds ratio [OR]: 5.62; 95% confidence interval [CI]: 1.52\u201320.82) and donation after brain death (OR: 2.21; 95% CI: 1.00\u20134.88) were associated with posttransplant HPgV\u20101 infection, whereas pretransplant hypertension was protective (OR: 0.23; 95% CI: 0.09\u20130.55). There were no significant differences in the incidence of study outcomes according to HPgV\u20101 status. Plasma HPgV\u20101 RNA levels at different points did not significantly differ between patients that subsequently developed outcomes and those remaining free from these events. No correlation between HPgV\u20101 RNA and immune parameters or torque teno virus DNA load was observed either.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unlike patients living with HIV, HPgV\u20101 infection does not seem to influence patient or graft outcomes after KT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13771","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T19:44:17Z","timestamp":1639856657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Human pegivirus type 1 infection in kidney transplant recipients: Replication kinetics and clinical correlates"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"first","affiliation":[{"name":"Department of Medicine School of Medicine Universidad Complutense  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