{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:36:41Z","timestamp":1753879001165,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The mortality of coronavirus disease 2019 (COVID\u201019) is high in transplant patients, and effective vaccination is aimed to reduce severe disease and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study to evaluate humoral and cellular response to two 4\u2010\u03bcg doses of BBIBP\u2010CorV vaccine in 100 kidney transplant recipients, using anti\u2010spike IgG, total anti\u2010receptor\u2010binding domain, neutralizing antibody (Ab) level (enzyme\u2010linked immunoassay), and interferon\u2010gamma release assay (IGRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seroconversion was evaluated 85.84 \u00b1 30.72 days after the second dose. Note that, 58% of all and 43.05% of infection\u2010na\u00efve participants have developed at least one of the tested antibodies. IGRA was positive in 30.7% of tested transplant recipients. Sixty percent of the participants had either humoral or cellular responses to COVID\u201019. Only age was independently linked to seropositivity of any degree after vaccination (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). COVID\u2010na\u00efve patients older than 60 years developed significantly less neutralizing Abs. (<jats:italic>p<\/jats:italic> = .011). Six patients developed mild COVID infection more than a month after the second dose of the vaccine (54.5 \u00b1 20.8 days). No vaccine\u2010related adverse effects were reported, except self\u2010limited mild to moderate fever and injection site pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BBIBP\u2010CorV vaccine can be used safely in kidney transplant recipients, although impaired cellular and humoral immunity necessitate adjustments in vaccination strategies, like higher (8\u2010\u03bcg doses), fourth booster dose, or boost with different platform vaccine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13798","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T14:16:44Z","timestamp":1642774604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Humoral immunity of BBIBP\u2010CorV (Sinopharm) in kidney transplant recipients: Is it time to revise vaccination strategies"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-2666","authenticated-orcid":false,"given":"Mohsen","family":"Nafar","sequence":"first","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-6781","authenticated-orcid":false,"given":"Saghar","family":"Chehrazi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Nephrology Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-0937","authenticated-orcid":false,"given":"Nooshin","family":"Dalili","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Nephrology Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Firouzan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Nephrology Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-8309","authenticated-orcid":false,"given":"Fatemeh","family":"Poorrezagholi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Nephrology Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-3198","authenticated-orcid":false,"given":"Fariba","family":"Samadian","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chronic Kidney Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Nephrology Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-7844","authenticated-orcid":false,"given":"Shiva","family":"Samavat","sequence":"additional","affiliation":[{"name":"Department of Nephrology Urology Nephrology Research Center (UNRC) Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99713-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13406"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9101097"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00578-z"},{"issue":"14","key":"e_1_2_8_6_1","first-page":"e151178","article-title":"Interpreting and addressing suboptimal immune responses after COVID\u201019 vaccination in solid\u2010organ transplant recipients","volume":"131","author":"Stock PG","year":"2021","journal-title":"J Clin 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