{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:42:59Z","timestamp":1779396179644,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Mycobacterium tuberculosis<\/jats:italic>can be transmitted via organ donation and result in severe outcomes. To better understand donor\u2010derived tuberculosis (DDTB), all potential transmissions reported to the Organ Procurement and Transplantation Network (OPTN) Ad Hoc Disease Transmission Advisory Committee between 2008 and 2018 were analyzed. Among 51 total reports, nine (17%) (9 donors\/35 recipients) had\u00a0\u2265\u00a01 recipient with proven\/probable disease transmission. Of these, eight were reported due to recipient disease, and one was reported due to a positive donor result. Proven\/probable DDTB transmissions were reported in six lung and five nonlung recipients. The median time to diagnosis was 104 days posttransplant (range 0\u2013165 days). Pulmonary TB, extrapulmonary TB, pulmonary plus extrapulmonary TB, and asymptomatic TB infection with positive interferon\u2010gamma release assay were present in five, three, one, and two recipients, respectively. All recipients received treatment and survived except for one whose death was not attributed to TB. All donors associated with proven\/probable DDTB had\u00a0\u2265\u00a01\u00a0TB risk factor. Six were born in a TB\u2010endemic country, five had traveled to a TB\u2010endemic country, three had been incarcerated, and three had latent TB infection. These cases highlight the importance of evaluating donors for TB based on risk factors. Early posttransplant TB in organ recipients of donors with TB risk factors requires prompt reporting to OPTN to identify other potential affected recipients and implement timely treatment interventions.<\/jats:p>","DOI":"10.1111\/tid.13800","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T10:18:29Z","timestamp":1642846709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Donor\u2010derived tuberculosis among solid organ transplant recipients in the United States\u20142008 to 2018"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-9994","authenticated-orcid":false,"given":"Maricar","family":"Malinis","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3192","authenticated-orcid":false,"given":"Ricardo M.","family":"La Hoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Geographic Medicine University of Texas Southwestern Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-2506","authenticated-orcid":false,"given":"Gabriel","family":"Vece","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Annambhotla","sequence":"additional","affiliation":[{"name":"Centers for Disease Control Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-5629","authenticated-orcid":false,"given":"Saima","family":"Aslam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health University of California San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar V.","family":"Basavaraju","sequence":"additional","affiliation":[{"name":"Centers for Disease Control Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Bucio","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-5221","authenticated-orcid":false,"given":"Lara","family":"Danziger\u2010Isakov","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital 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York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-5030","authenticated-orcid":false,"given":"Cameron R.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Duke University Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-0544","authenticated-orcid":false,"given":"Marian G.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UPMC Children's Hospital of Pittsburgh and University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/514993"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/599036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/599035"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050842"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13259"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16178"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"e13548","DOI":"10.1111\/ctr.13548","article-title":"Screening of donor and candidate prior to solid organ transplantation\u2014guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","author":"Malinis M","year":"2019","journal-title":"Clin 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