{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:59:51Z","timestamp":1790200791934,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Candidiasis is the most common invasive fungal infection in solid organ transplant recipients, and liver transplant (LT) recipients are at heightened risk. We hypothesized that pre\u2010transplant screening for azole non\u2010susceptible <jats:italic>Candida<\/jats:italic> (ANSC) allows for tailored antifungal prophylaxis to reduce the incidence of post\u2010LT ANSC infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of adult (age \u226518 years) patients who underwent LT at Yale New Haven Hospital from April 2019 to March 2021. Screening for ANSC, defined as <jats:italic>Candida glabrata<\/jats:italic> or <jats:italic>Candida krusei<\/jats:italic>, was performed using a rectal swab prior to or at the time of LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, ANSC screening was performed in 47 patients who underwent a total of 48 LTs, with 46\/48 (96%) primary LTs and two re\u2010transplantations. Ten of 48 screened cases (21%) had ANSC\u2010positive rectal swabs. Only seven of 10 ANSC\u2010colonized patients received appropriate antifungal prophylaxis (i.e., anidulafungin), and one of these seven patients developed candidemia within 30 days of LT. The median number of candidiasis risk factors was one, and 29% of the cohort had two or more risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Routine ANSC screening of LT candidates may assist in selecting appropriate antifungal prophylaxis but may be insufficient to prevent infection in those with multiple risk factors for <jats:italic>Candida<\/jats:italic> infection<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13811","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T19:53:15Z","timestamp":1645386795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rectal screening for azole non\u2010susceptible <i>Candida<\/i> species in patients undergoing liver transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-1482","authenticated-orcid":false,"given":"Christopher","family":"Radcliffe","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-3069","authenticated-orcid":false,"given":"Kishan K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-5042","authenticated-orcid":false,"given":"Marwan M.","family":"Azar","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-7860","authenticated-orcid":false,"given":"Alan","family":"Koff","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases UC Davis School of Medicine  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen D.","family":"Belfield","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-5012","authenticated-orcid":false,"given":"David R.","family":"Peaper","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-2352","authenticated-orcid":false,"given":"Jeffrey E.","family":"Topal","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-9994","authenticated-orcid":false,"given":"Maricar","family":"Malinis","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut 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